Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3977914..3978574 Replicon chromosome
Accession NZ_CP043398
Organism Leclercia adecarboxylata strain G426

Toxin (Protein)


Gene name cptA Uniprot ID A0A7H0FEK5
Locus tag FY047_RS18640 Protein ID WP_032613858.1
Coordinates 3977914..3978327 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G7TIV6
Locus tag FY047_RS18645 Protein ID WP_032613860.1
Coordinates 3978308..3978574 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY047_RS18620 3973912..3975645 - 1734 WP_103792603.1 single-stranded-DNA-specific exonuclease RecJ -
FY047_RS18625 3975651..3976364 - 714 WP_032613852.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FY047_RS18630 3976390..3977286 - 897 WP_032613854.1 site-specific tyrosine recombinase XerD -
FY047_RS18635 3977388..3977909 + 522 WP_059307242.1 flavodoxin FldB -
FY047_RS18640 3977914..3978327 - 414 WP_032613858.1 protein YgfX Toxin
FY047_RS18645 3978308..3978574 - 267 WP_032613860.1 FAD assembly factor SdhE Antitoxin
FY047_RS18650 3978879..3979859 + 981 WP_032613862.1 tRNA-modifying protein YgfZ -
FY047_RS18655 3979989..3980648 - 660 WP_032613865.1 hemolysin III family protein -
FY047_RS18660 3980814..3981125 - 312 WP_032613867.1 N(4)-acetylcytidine aminohydrolase -
FY047_RS18665 3981178..3981909 + 732 WP_032613869.1 MurR/RpiR family transcriptional regulator -
FY047_RS18670 3982022..3983455 + 1434 WP_103792605.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16231.98 Da        Isoelectric Point: 10.6531

>T138657 WP_032613858.1 NZ_CP043398:c3978327-3977914 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Download         Length: 414 bp

>T138657 NZ_CP058191:c4838518-4838147 [Enterobacter hormaechei]
ATGGAGCACATGGCTGTGTTTGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGGGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.06 Da        Isoelectric Point: 4.6787

>AT138657 WP_032613860.1 NZ_CP043398:c3978574-3978308 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138657 NZ_CP058191:c4838763-4838521 [Enterobacter hormaechei]
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTCGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0FEK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7TIV6

References