Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2309547..2311112 Replicon chromosome
Accession NZ_CP043398
Organism Leclercia adecarboxylata strain G426

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FY047_RS10835 Protein ID WP_103792381.1
Coordinates 2309547..2310857 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FY047_RS10840 Protein ID WP_103792380.1
Coordinates 2310861..2311112 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY047_RS10820 2305028..2306209 - 1182 WP_032618094.1 PLP-dependent aminotransferase family protein -
FY047_RS10825 2306342..2308339 - 1998 WP_103792383.1 TonB-dependent receptor -
FY047_RS10830 2308350..2309411 - 1062 WP_103792382.1 YncE family protein -
FY047_RS10835 2309547..2310857 - 1311 WP_103792381.1 type II toxin-antitoxin system HipA family toxin Toxin
FY047_RS10840 2310861..2311112 - 252 WP_103792380.1 helix-turn-helix domain-containing protein Antitoxin
FY047_RS10845 2311912..2315712 + 3801 WP_164529816.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48226.38 Da        Isoelectric Point: 6.5043

>T138647 WP_103792381.1 NZ_CP043398:c2310857-2309547 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLDGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEA
DSAFRMAPLYDVISAFPLFDAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAYAGYSQEAARRLLAEMAERTDDV
IASVRAELPPDFPVQVSEAIFKGLASQAARIGRFVS

Download         Length: 1311 bp

>T138647 NZ_CP043398:c2310857-2309547 [Leclercia adecarboxylata]
ATGCGCGCACAACGACTGACTGTCGCGATGAATGGCGACGTAGTGGGTACGCTGCATCGTGACGGCAGCGGGGCAATGTC
CTTCCAGTATGCCCCGGAGTGGCTGGCCGAGCCGGGTTCGCGCGCGATTTCGCTCTCTTTGCCGCTACAGCACGGCAGGA
TCAGAGGCGCGCAGGTCTTTAATTTCTTCAGTAATCTGCTGCCTGACTCCGAAGCGATTATTGCCCGCATGCAGGCCCGA
TTCCAGGTTGAAACCGCTCATCCCTTTGATCTGCTGGCCAGTGTCGGGCGTGACTGTGTGGGCGCCATTCAGCTCTATCC
GCCGGGACAGGAGATCCCCCCGGTAACAGATATCGTGGCCGAACCGCTGGATGACGATCAGATTGCCGCGCTGCTCGACG
GGTATCAGATGGCACCGCTGGGGATGACCGAGGAGGATGCCGACTTTCGCATTTCGCTGGCCGGCGCGCAGGAAAAGACG
GCGCTGCTATGGTACCAGGCACGCTGGCAGCGGCCCCAGGGTAGCACCCCAACCAGTCACATCTTTAAGCTGCCGATCGG
CAGAATAGAACAAAACAATATCGACCTGAGCGAAAGTTGTGAAAACGAATGGCTGTGTTTGCGCATTGCCAAAGCCTTTG
GTTTCCCAGTGGCACAGGCGGAGATGGCAACCTTTGGCCGCAAGAAAGTGCTGATTATCGAGCGTTTCGACCGTCGTTGG
TCCAGCAGCGGGTGGCTGATGCGCCTGCCGCAGGAAGATTTTTGCCAGGCCCTGGGCGTGTCCCCAGCGCTGAAATATGA
ATCTCACGGTGGTCCCGGGATTGCCGACGCCATGAAGCTGCTGCTCGGTTCCCGCCTGGCGGGGCAGGATCGCGAGCTGT
TCTTTAAGGCGCAGATCCTGTTCTGGATGCTGGCCGCCATTGATGGTCACGGGAAGAATTTCAGCCTGTTTATCGAGGCG
GATTCCGCCTTTCGCATGGCCCCGCTGTACGACGTGATTTCCGCGTTTCCGCTGTTCGACGCAGGGGGGATCCCGGTCAA
AAAAGCGAAGATGGCGATGGCGTTACAGGGCAAGAACCGGCAGTACCATTTTGCGATGATCCAACCGCGTCACTTTATCA
GCACCGCTGCTTATGCAGGTTATTCCCAGGAGGCCGCTCGCCGTTTGCTGGCCGAGATGGCGGAGCGAACAGACGACGTT
ATTGCCTCCGTCAGGGCAGAATTGCCACCGGATTTCCCCGTGCAGGTCAGTGAGGCCATTTTTAAGGGGTTAGCCAGCCA
GGCGGCAAGAATAGGGCGGTTCGTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9237.63 Da        Isoelectric Point: 10.3698

>AT138647 WP_103792380.1 NZ_CP043398:c2311112-2310861 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDKNAWK
KEW

Download         Length: 252 bp

>AT138647 NZ_CP058188:63036-63266 [Enterobacter hormaechei]
ATGCGCACAGTTTCTATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCATTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References