Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1354366..1355002 Replicon chromosome
Accession NZ_CP043398
Organism Leclercia adecarboxylata strain G426

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag FY047_RS06310 Protein ID WP_150872787.1
Coordinates 1354637..1355002 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FY047_RS06305 Protein ID WP_150870274.1
Coordinates 1354366..1354596 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY047_RS06285 1351308..1352696 - 1389 WP_150870267.1 DEAD/DEAH box helicase family protein -
FY047_RS06290 1352690..1353259 - 570 WP_164529694.1 hypothetical protein -
FY047_RS06295 1353358..1353669 + 312 WP_150870270.1 helix-turn-helix domain-containing protein -
FY047_RS06300 1353771..1353989 - 219 WP_150870272.1 hypothetical protein -
FY047_RS06305 1354366..1354596 + 231 WP_150870274.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FY047_RS06310 1354637..1355002 + 366 WP_150872787.1 PIN domain-containing protein Toxin
FY047_RS06315 1355220..1355987 + 768 WP_150870276.1 hypothetical protein -
FY047_RS06320 1356057..1356725 + 669 WP_150870278.1 response regulator -
FY047_RS06325 1356701..1358050 + 1350 WP_150870280.1 sensor histidine kinase -
FY047_RS06330 1358264..1358740 - 477 WP_150870282.1 WbuC family cupin fold metalloprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 12905.93 Da        Isoelectric Point: 7.1676

>T138646 WP_150872787.1 NZ_CP043398:1354637-1355002 [Leclercia adecarboxylata]
MREQPEAVLKRLEQAVLRNQRIVISAISWSEISLAARAAGPATQQLANAFCARLDAILPWDRGAVDATTDIKVALRLAGT
TIGPNHTLIAGHAIAAGAVLVTMKGGEFERVPGLVLEDWVN

Download         Length: 366 bp

>T138646 NZ_CP043398:1354637-1355002 [Leclercia adecarboxylata]
ATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCTGGAGCAGGCGGTACTGCGCAACCAGCGCATCGTGATCTCGGCCAT
ATCCTGGTCTGAGATTTCACTGGCCGCCCGGGCTGCGGGGCCTGCCACACAGCAGCTGGCTAACGCGTTCTGCGCCCGCC
TCGATGCCATCCTGCCCTGGGACCGCGGCGCGGTGGATGCGACCACGGATATTAAGGTGGCGTTGCGCCTCGCCGGGACG
ACGATCGGCCCGAATCACACATTGATTGCCGGGCACGCCATTGCTGCCGGCGCCGTACTGGTGACAATGAAAGGGGGGGA
GTTTGAGCGGGTGCCGGGCCTGGTGCTGGAAGACTGGGTTAACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8663.88 Da        Isoelectric Point: 4.8011

>AT138646 WP_150870274.1 NZ_CP043398:1354366-1354596 [Leclercia adecarboxylata]
MRTVSIFKNGNNRAIRLPRNLDIEGVSELEIVREGDRIILRPVRPIWGSFAQLEKADPDFMAERGDVVTDEGRVDL

Download         Length: 231 bp

>AT138646 NZ_CP058188:59497-59727 [Enterobacter hormaechei]
ATGAGAACCGTATCTATTTTCAAAAATGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References