Detailed information of TA system TA138646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1354366..1355002
• Replicon: chromosome
• Accession: NZ_CP043398
• Organism: Leclercia adecarboxylata strain G426

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: FY047_RS06310
• Protein ID: WP_150872787.1
• Coordinates: 1354637..1355002 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: FY047_RS06305
• Protein ID: WP_150870274.1
• Coordinates: 1354366..1354596 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY047_RS06285	1351308..1352696	-	1389	WP_150870267.1	DEAD/DEAH box helicase family protein	-
FY047_RS06290	1352690..1353259	-	570	WP_164529694.1	hypothetical protein	-
FY047_RS06295	1353358..1353669	+	312	WP_150870270.1	helix-turn-helix domain-containing protein	-
FY047_RS06300	1353771..1353989	-	219	WP_150870272.1	hypothetical protein	-
FY047_RS06305	1354366..1354596	+	231	WP_150870274.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FY047_RS06310	1354637..1355002	+	366	WP_150872787.1	PIN domain-containing protein	Toxin
FY047_RS06315	1355220..1355987	+	768	WP_150870276.1	hypothetical protein	-
FY047_RS06320	1356057..1356725	+	669	WP_150870278.1	response regulator	-
FY047_RS06325	1356701..1358050	+	1350	WP_150870280.1	sensor histidine kinase	-
FY047_RS06330	1358264..1358740	-	477	WP_150870282.1	WbuC family cupin fold metalloprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 12905.93 Da
• Isoelectric Point: 7.1676

>T138646 WP_150872787.1 NZ_CP043398:1354637-1355002 [Leclercia adecarboxylata]
MREQPEAVLKRLEQAVLRNQRIVISAISWSEISLAARAAGPATQQLANAFCARLDAILPWDRGAVDATTDIKVALRLAGT
TIGPNHTLIAGHAIAAGAVLVTMKGGEFERVPGLVLEDWVN

Nucleotide

• Length: 366 bp

>T138646 NZ_CP043398:1354637-1355002 [Leclercia adecarboxylata]
ATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCTGGAGCAGGCGGTACTGCGCAACCAGCGCATCGTGATCTCGGCCAT
ATCCTGGTCTGAGATTTCACTGGCCGCCCGGGCTGCGGGGCCTGCCACACAGCAGCTGGCTAACGCGTTCTGCGCCCGCC
TCGATGCCATCCTGCCCTGGGACCGCGGCGCGGTGGATGCGACCACGGATATTAAGGTGGCGTTGCGCCTCGCCGGGACG
ACGATCGGCCCGAATCACACATTGATTGCCGGGCACGCCATTGCTGCCGGCGCCGTACTGGTGACAATGAAAGGGGGGGA
GTTTGAGCGGGTGCCGGGCCTGGTGCTGGAAGACTGGGTTAACTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8663.88 Da
• Isoelectric Point: 4.8011

>AT138646 WP_150870274.1 NZ_CP043398:1354366-1354596 [Leclercia adecarboxylata]
MRTVSIFKNGNNRAIRLPRNLDIEGVSELEIVREGDRIILRPVRPIWGSFAQLEKADPDFMAERGDVVTDEGRVDL

Nucleotide

• Length: 231 bp

>AT138646 NZ_CP058188:59497-59727 [Enterobacter hormaechei]
ATGAGAACCGTATCTATTTTCAAAAATGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTAACCTGTGA