Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3942131..3942791 Replicon chromosome
Accession NZ_CP043397
Organism Leclercia adecarboxylata strain L21

Toxin (Protein)


Gene name cptA Uniprot ID A0A7H0FEK5
Locus tag FY044_RS18880 Protein ID WP_032613858.1
Coordinates 3942131..3942544 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G7TIV6
Locus tag FY044_RS18885 Protein ID WP_032613860.1
Coordinates 3942525..3942791 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY044_RS18860 3938129..3939862 - 1734 WP_130588241.1 single-stranded-DNA-specific exonuclease RecJ -
FY044_RS18865 3939868..3940581 - 714 WP_032613852.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FY044_RS18870 3940607..3941503 - 897 WP_032613854.1 site-specific tyrosine recombinase XerD -
FY044_RS18875 3941605..3942126 + 522 WP_164541027.1 flavodoxin FldB -
FY044_RS18880 3942131..3942544 - 414 WP_032613858.1 protein YgfX Toxin
FY044_RS18885 3942525..3942791 - 267 WP_032613860.1 FAD assembly factor SdhE Antitoxin
FY044_RS18890 3943096..3944076 + 981 WP_032613862.1 tRNA-modifying protein YgfZ -
FY044_RS18895 3944206..3944865 - 660 WP_032613865.1 hemolysin III family protein -
FY044_RS18900 3945031..3945342 - 312 WP_032613867.1 N(4)-acetylcytidine aminohydrolase -
FY044_RS18905 3945395..3946126 + 732 WP_032613869.1 MurR/RpiR family transcriptional regulator -
FY044_RS18910 3946239..3947672 + 1434 WP_164541029.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16231.98 Da        Isoelectric Point: 10.6531

>T138643 WP_032613858.1 NZ_CP043397:c3942544-3942131 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Download         Length: 414 bp

>T138643 NZ_CP058187:3567211-3567540 [Enterobacter hormaechei]
ATGAAAACTCTACCTGCTACAATTTCTCGGGCGGCGAAGCCTTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGGGATCAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCACCCTGGCCGATGCAGTCAACTTTCTGGTGGATAAGTACGAACTAGTTCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAGCAGACCCCGTATCTTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGATTGCTAAAAGCCAA
GGTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.06 Da        Isoelectric Point: 4.6787

>AT138643 WP_032613860.1 NZ_CP043397:c3942791-3942525 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138643 NZ_CP043397:c3942791-3942525 [Leclercia adecarboxylata]
ATGGACATTACTAACAAAGCCCGCATTCATTGGGCATGCCGTCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
CTTCGAATACGAATACGACACCCTGAGCGATGAGGATAAAAAGCTGTTTATCCGCCTGCTGGAGAACGACGATCCTGATT
TATTTAACTGGTTAATGAATCACGGCGAACCCGCCGACGCCGAACTGCAACGGATGGTGCTTTTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0FEK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7TIV6

References