Detailed information of TA system TA138633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2359787..2361352
• Replicon: chromosome
• Accession: NZ_CP043397
• Organism: Leclercia adecarboxylata strain L21

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FY044_RS11390
• Protein ID: WP_164540339.1
• Coordinates: 2359787..2361097 (-)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FY044_RS11395
• Protein ID: WP_032618098.1
• Coordinates: 2361101..2361352 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY044_RS11375	2355269..2356450	-	1182	WP_032618094.1	PLP-dependent aminotransferase family protein	-
FY044_RS11380	2356583..2358580	-	1998	WP_059307942.1	TonB-dependent receptor	-
FY044_RS11385	2358591..2359652	-	1062	WP_059307941.1	YncE family protein	-
FY044_RS11390	2359787..2361097	-	1311	WP_164540339.1	type II toxin-antitoxin system HipA family toxin	Toxin
FY044_RS11395	2361101..2361352	-	252	WP_032618098.1	helix-turn-helix domain-containing protein	Antitoxin
FY044_RS11400	2362152..2365952	+	3801	WP_164540341.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-399)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 48210.38 Da
• Isoelectric Point: 6.5044

>T138633 WP_164540339.1 NZ_CP043397:c2361097-2359787 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLDGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVTQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEA
DSAFRMAPLYDVISAFPLFDAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGYSQEVARRLLAEMAERADDV
IASVRAELPPDFPAQVSEAIFKGLASQAARIGRFVS

Nucleotide

• Length: 1311 bp

>T138633 NZ_CP058180:2222785-2222888 [Klebsiella grimontii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9223.56 Da
• Isoelectric Point: 10.1945

>AT138633 WP_032618098.1 NZ_CP043397:c2361352-2361101 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDNNAWK
KEW

Nucleotide

• Length: 252 bp

>AT138633 NZ_CP058180:c2222895-2222727 [Klebsiella grimontii]
AATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGTGACAAAAGTG
GACGAATAA