Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2359787..2361352 Replicon chromosome
Accession NZ_CP043397
Organism Leclercia adecarboxylata strain L21

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FY044_RS11390 Protein ID WP_164540339.1
Coordinates 2359787..2361097 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FY044_RS11395 Protein ID WP_032618098.1
Coordinates 2361101..2361352 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY044_RS11375 2355269..2356450 - 1182 WP_032618094.1 PLP-dependent aminotransferase family protein -
FY044_RS11380 2356583..2358580 - 1998 WP_059307942.1 TonB-dependent receptor -
FY044_RS11385 2358591..2359652 - 1062 WP_059307941.1 YncE family protein -
FY044_RS11390 2359787..2361097 - 1311 WP_164540339.1 type II toxin-antitoxin system HipA family toxin Toxin
FY044_RS11395 2361101..2361352 - 252 WP_032618098.1 helix-turn-helix domain-containing protein Antitoxin
FY044_RS11400 2362152..2365952 + 3801 WP_164540341.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48210.38 Da        Isoelectric Point: 6.5044

>T138633 WP_164540339.1 NZ_CP043397:c2361097-2359787 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLDGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVTQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEA
DSAFRMAPLYDVISAFPLFDAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGYSQEVARRLLAEMAERADDV
IASVRAELPPDFPAQVSEAIFKGLASQAARIGRFVS

Download         Length: 1311 bp

>T138633 NZ_CP058180:2222785-2222888 [Klebsiella grimontii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9223.56 Da        Isoelectric Point: 10.1945

>AT138633 WP_032618098.1 NZ_CP043397:c2361352-2361101 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDNNAWK
KEW

Download         Length: 252 bp

>AT138633 NZ_CP058180:c2222895-2222727 [Klebsiella grimontii]
AATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGTGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References