Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1152276..1152895 Replicon chromosome
Accession NZ_CP043397
Organism Leclercia adecarboxylata strain L21

Toxin (Protein)


Gene name Hha Uniprot ID A0A345CDT0
Locus tag FY044_RS05555 Protein ID WP_032616864.1
Coordinates 1152276..1152494 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3E1ZZ82
Locus tag FY044_RS05560 Protein ID WP_032616865.1
Coordinates 1152503..1152895 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY044_RS05535 1149120..1149473 + 354 WP_059308601.1 DUF1428 family protein -
FY044_RS05540 1149506..1151074 - 1569 WP_164539979.1 EAL domain-containing protein -
FY044_RS05545 1151340..1151480 + 141 WP_032616862.1 type B 50S ribosomal protein L36 -
FY044_RS05550 1151540..1152004 - 465 WP_032616863.1 membrane protein -
FY044_RS05555 1152276..1152494 - 219 WP_032616864.1 hemolysin expression modulator Hha Toxin
FY044_RS05560 1152503..1152895 - 393 WP_032616865.1 Hha toxicity modulator TomB Antitoxin
FY044_RS05565 1153387..1156527 - 3141 WP_059308599.1 multidrug efflux RND transporter permease subunit AcrB -
FY044_RS05570 1156550..1157743 - 1194 WP_032616867.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1141120..1152895 11775


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T138631 WP_032616864.1 NZ_CP043397:c1152494-1152276 [Leclercia adecarboxylata]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T138631 NZ_CP043397:c1152494-1152276 [Leclercia adecarboxylata]
ATGTCTGATAAACCCTTAACCAAGACAGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATTGACACCCTTGAACGTGT
GATTGAGAAAAATAAATACGAGCTTTCTGATAATGAGTTAGCAGTATTCTATTCTGCAGCCGATCATCGTCTGGCTGAAC
TCACTATGAATAAGCTGTATGATAAAATCCCGACAGCCGTGTGGAAGTTTGTACGCTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15093.98 Da        Isoelectric Point: 4.8941

>AT138631 WP_032616865.1 NZ_CP043397:c1152895-1152503 [Leclercia adecarboxylata]
MDEYSPKRQDIAQLKFLCESLYHDCLSNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNASKANPLASPVKIITNN

Download         Length: 393 bp

>AT138631 NZ_CP058180:895982-896248 [Klebsiella grimontii]
ATGGATATTAACAATAAAGCTCGCATCCACTGGGCATGCCGCCGGGGAATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGATACGCTCAGTGATGACGATAAGCGGTTGTTCATCCGCCTGCTGGAAAATGACGATCCGGACC
TGTTCAACTGGTTGATGAACCATGGCGAACCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345CDT0

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1ZZ82

References