Detailed information of TA system TA138629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 4892736..4893322
• Replicon: chromosome
• Accession: NZ_CP043396
• Organism: Pseudomonas monteilii strain 170620603RE

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: FY043_RS23285
• Protein ID: WP_082426425.1
• Coordinates: 4893029..4893322 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A923H277
• Locus tag: FY043_RS23280
• Protein ID: WP_060499950.1
• Coordinates: 4892736..4893032 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY043_RS23260	4889704..4890645	-	942	WP_164525071.1	FecR domain-containing protein	-
FY043_RS23265	4890645..4891157	-	513	WP_164525274.1	sigma-70 family RNA polymerase sigma factor	-
FY043_RS23270	4891447..4892094	+	648	WP_060499948.1	hypothetical protein	-
FY043_RS23275	4892246..4892734	+	489	WP_164525072.1	GNAT family N-acetyltransferase	-
FY043_RS23280	4892736..4893032	-	297	WP_060499950.1	putative addiction module antidote protein	Antitoxin
FY043_RS23285	4893029..4893322	-	294	WP_082426425.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY043_RS23290	4893544..4894431	+	888	WP_164525073.1	effector protein	-
FY043_RS23295	4894428..4895195	-	768	WP_060499952.1	phosphonate ABC transporter, permease protein PhnE	-
FY043_RS23300	4895192..4896019	-	828	WP_060499953.1	ABC transporter permease subunit	-
FY043_RS23305	4896013..4896822	-	810	WP_164525074.1	ATP-binding cassette domain-containing protein	-
FY043_RS23310	4896819..4897673	-	855	WP_164525075.1	putative selenate ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4846218..4894431	48213

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-95)

Antitoxin

• Uncharacterized protein HI1420 (4-93)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10847.80 Da
• Isoelectric Point: 10.5184

>T138629 WP_082426425.1 NZ_CP043396:c4893322-4893029 [Pseudomonas monteilii]
MYLVEQTESFAVWLSSLRDLKAKLAIGRRLERVAIGNLGDFKWLGGGLGELRIDVGAGYRVYFTQKGHRLVLLLVGGDKS
TQVADILKSRKLLKEMI

Nucleotide

• Length: 294 bp

>T138629 NZ_CP058177:46844-47185 [Enterobacter hormaechei]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCTGTGGCAGTCTGGCAAATGCTGCTTGC
TCGCCTGCTGGAACAACATTATGGCCTGACGCTAAACGACACGCCGTTCAGTGATGAAAAGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GGCTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACAGGTTTATTGAAAGCGCG
GCACGGTGAACATTGGGAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10587.22 Da
• Isoelectric Point: 6.2205

>AT138629 WP_060499950.1 NZ_CP043396:c4893032-4892736 [Pseudomonas monteilii]
MSEKLIPFDMAALLSSDEAISEYLSQVLSDGDTEEIIRALGHIARARGMTHIATESGLGRESLYKALSPGAKPRFDTVLK
VIRALGVDLLVQPHAVAR

Nucleotide

• Length: 297 bp

>AT138629 NZ_CP058177:46482-46823 [Enterobacter hormaechei]
ATGAAATCTACTGATTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAATCGACTGCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATTTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGGTGAAATAAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATTCCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCTCACTTATCGTTAA