Detailed information of TA system TA138626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 3481254..3481807
• Replicon: chromosome
• Accession: NZ_CP043396
• Organism: Pseudomonas monteilii strain 170620603RE

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FY043_RS16335
• Protein ID: WP_164524678.1
• Coordinates: 3481254..3481547 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FY043_RS16340
• Protein ID: WP_096862010.1
• Coordinates: 3481535..3481807 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY043_RS16300	3476258..3476512	+	255	WP_164524675.1	hypothetical protein	-
FY043_RS16305	3476509..3477075	+	567	WP_060497295.1	hypothetical protein	-
FY043_RS16310	3477119..3477442	+	324	WP_060497296.1	helix-turn-helix domain-containing protein	-
FY043_RS16315	3477498..3477824	+	327	WP_060497297.1	hypothetical protein	-
FY043_RS16320	3477887..3478063	+	177	WP_164524676.1	hypothetical protein	-
FY043_RS16325	3478358..3479536	+	1179	Protein_3182	tyrosine-type recombinase/integrase	-
FY043_RS16330	3479851..3481260	+	1410	WP_164524677.1	site-specific integrase	-
FY043_RS16335	3481254..3481547	-	294	WP_164524678.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY043_RS16340	3481535..3481807	-	273	WP_096862010.1	CopG family ribbon-helix-helix protein	Antitoxin
FY043_RS16345	3482242..3483672	-	1431	WP_164524679.1	dynamin family protein	-
FY043_RS16350	3483731..3484768	+	1038	WP_079452737.1	IS630-like element ISPa47 family transposase	-
FY043_RS16355	3484791..3485078	-	288	WP_164524680.1	hypothetical protein	-
FY043_RS16360	3485065..3486801	-	1737	WP_164524681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	aph(6)-Id / aph(3'')-Ib / sul1 / cmlA1 / aac(6')-IIa	-	3474232..3535882	61650
	-	flank	IS/Tn	-	-	3483731..3484768	1037

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11183.67 Da
• Isoelectric Point: 5.9081

>T138626 WP_164524678.1 NZ_CP043396:c3481547-3481254 [Pseudomonas monteilii]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQVIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T138626 NZ_CP058175:c2821587-2821484 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10494.66 Da
• Isoelectric Point: 6.7193

>AT138626 WP_096862010.1 NZ_CP043396:c3481807-3481535 [Pseudomonas monteilii]
MATSIKIDDKLKGRIQQLASQRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTSQETRTWLGSWGTD
TEAELPKCHD

Nucleotide

• Length: 273 bp

>AT138626 NZ_CP043396:c3481807-3481535 [Pseudomonas monteilii]
ATGGCCACTTCCATCAAAATTGATGACAAGCTAAAAGGCCGCATTCAGCAGTTGGCGAGCCAACGCCAGCGCTCGTCTCA
CTGGATCATGCGCGAGGCAATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTTAAGCAGGAAGCCCTGGCAT
CGTGGGCGGCATATCAGGAAACCGGACGGCATTTGACCAGCCAAGAAACTCGGACCTGGCTCGGTAGCTGGGGAACAGAT
ACTGAGGCAGAGTTGCCCAAGTGCCACGACTGA