Detailed information of TA system TA138621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 3482363..3482916
• Replicon: chromosome
• Accession: NZ_CP043395
• Organism: Pseudomonas monteilii strain 170918607

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FY041_RS16350
• Protein ID: WP_164524678.1
• Coordinates: 3482363..3482656 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FY041_RS16355
• Protein ID: WP_096862010.1
• Coordinates: 3482644..3482916 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY041_RS16315	3477367..3477621	+	255	WP_164524675.1	hypothetical protein	-
FY041_RS16320	3477618..3478184	+	567	WP_060497295.1	hypothetical protein	-
FY041_RS16325	3478228..3478551	+	324	WP_060497296.1	helix-turn-helix domain-containing protein	-
FY041_RS16330	3478607..3478933	+	327	WP_060497297.1	hypothetical protein	-
FY041_RS16335	3478996..3479172	+	177	WP_164524676.1	hypothetical protein	-
FY041_RS16340	3479467..3480645	+	1179	Protein_3183	tyrosine-type recombinase/integrase	-
FY041_RS16345	3480960..3482369	+	1410	WP_164524677.1	site-specific integrase	-
FY041_RS16350	3482363..3482656	-	294	WP_164524678.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY041_RS16355	3482644..3482916	-	273	WP_096862010.1	CopG family ribbon-helix-helix protein	Antitoxin
FY041_RS16360	3483351..3484781	-	1431	WP_164524679.1	dynamin family protein	-
FY041_RS16365	3484840..3485877	+	1038	WP_079452737.1	IS630-like element ISPa47 family transposase	-
FY041_RS16370	3485900..3486187	-	288	WP_164524680.1	hypothetical protein	-
FY041_RS16375	3486174..3487910	-	1737	WP_164524681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	aph(6)-Id / aph(3'')-Ib / sul1 / cmlA1 / aac(6')-IIa	-	3475341..3536991	61650
	-	flank	IS/Tn	-	-	3484840..3485877	1037

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11183.67 Da
• Isoelectric Point: 5.9081

>T138621 WP_164524678.1 NZ_CP043395:c3482656-3482363 [Pseudomonas monteilii]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQVIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T138621 NZ_CP058172:c4979825-4979514 [Enterobacter hormaechei]
ATGCTATTCATTGAAACGGATATTTTTACAGAAGACGTCAAAACGTTACTGGATGACGACGAATATCATAGGTTCCAAAT
ATTCCTGGCAACGCAACCGGATTACGGCGATCTGATCCAGAATTCGGGAGGCTTGCGAAAGATTCGCTGGCTTGCTGGCG
GTAAGGGAAAGCGTAGTGGAGTCAGAGTTATCTATTTTCACCGTACGCGTGAGTGTGAAATCAGGTTGCTGCTCATCTAT
CGCAAAGGGATCAAAGATGACCTCTCCGCGGGTGAAAAAGCCATACTGAAAAAGATGATTGAGAGGTGGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10494.66 Da
• Isoelectric Point: 6.7193

>AT138621 WP_096862010.1 NZ_CP043395:c3482916-3482644 [Pseudomonas monteilii]
MATSIKIDDKLKGRIQQLASQRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTSQETRTWLGSWGTD
TEAELPKCHD

Nucleotide

• Length: 273 bp

>AT138621 NZ_CP043395:c3482916-3482644 [Pseudomonas monteilii]
ATGGCCACTTCCATCAAAATTGATGACAAGCTAAAAGGCCGCATTCAGCAGTTGGCGAGCCAACGCCAGCGCTCGTCTCA
CTGGATCATGCGCGAGGCAATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTTAAGCAGGAAGCCCTGGCAT
CGTGGGCGGCATATCAGGAAACCGGACGGCATTTGACCAGCCAAGAAACTCGGACCTGGCTCGGTAGCTGGGGAACAGAT
ACTGAGGCAGAGTTGCCCAAGTGCCACGACTGA