Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2213740..2214254 Replicon chromosome
Accession NZ_CP043392
Organism Staphylococcus aureus strain NRS384-rpoB-H481N-NCV

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FZC50_RS11355 Protein ID WP_000581792.1
Coordinates 2213740..2213949 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FZC50_RS11360 Protein ID WP_000138932.1
Coordinates 2213961..2214254 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZC50_RS11335 2209248..2210606 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FZC50_RS11340 2210621..2211691 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
FZC50_RS11345 2212009..2213211 + 1203 WP_001109939.1 rod shape-determining protein RodA -
FZC50_RS11350 2213475..2213612 - 138 WP_000828354.1 hypothetical protein -
FZC50_RS11355 2213740..2213949 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FZC50_RS11360 2213961..2214254 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FZC50_RS11365 2214420..2215904 + 1485 WP_000571549.1 cardiolipin synthase -
FZC50_RS11370 2215932..2216579 + 648 WP_001187629.1 HD domain-containing protein -
FZC50_RS11390 2217392..2218264 - 873 WP_000725802.1 membrane protein insertase YidC -
FZC50_RS11395 2218350..2218991 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T138613 WP_000581792.1 NZ_CP043392:c2213949-2213740 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T138613 NZ_CP058168:c55078-54767 [Enterobacter hormaechei]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT138613 WP_000138932.1 NZ_CP043392:c2214254-2213961 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT138613 NZ_CP058168:c54770-54351 [Enterobacter hormaechei]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References