Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1513071..1513548 Replicon chromosome
Accession NZ_CP043389
Organism Staphylococcus aureus strain NRS384-rpoB-H481N-SCV

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag FZC51_RS07490 Protein ID WP_000052078.1
Coordinates 1513360..1513548 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FZC51_RS07485 Protein ID WP_001059690.1
Coordinates 1513071..1513331 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZC51_RS07450 1508464..1509180 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
FZC51_RS07455 1509328..1509750 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
FZC51_RS07460 1510149..1510643 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
FZC51_RS07465 1510798..1511415 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FZC51_RS07470 1511488..1512069 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
FZC51_RS07475 1512294..1512530 + 237 WP_000368687.1 hypothetical protein -
FZC51_RS07480 1512527..1512730 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FZC51_RS07485 1513071..1513331 + 261 WP_001059690.1 hypothetical protein Antitoxin
FZC51_RS07490 1513360..1513548 + 189 WP_000052078.1 hypothetical protein Toxin
FZC51_RS07495 1513736..1514305 + 570 WP_001106654.1 hypothetical protein -
FZC51_RS07500 1514393..1514677 + 285 WP_001004395.1 hypothetical protein -
FZC51_RS07505 1514739..1514957 + 219 WP_000005886.1 hypothetical protein -
FZC51_RS07510 1515453..1515653 - 201 WP_001059082.1 cold-shock protein -
FZC51_RS07515 1516010..1516696 - 687 WP_001548082.1 thermonuclease family protein -
FZC51_RS07520 1517037..1517507 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk 1487782..1517507 29725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T138590 WP_000052078.1 NZ_CP043389:1513360-1513548 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T138590 NZ_CP043389:1513360-1513548 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT138590 WP_001059690.1 NZ_CP043389:1513071-1513331 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT138590 NZ_CP058160:c2882694-2882392 [Enterobacter hormaechei]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGGCGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTGCCCGATGGTTCTCATTACGAGTTTGTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References