Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 888882..889359 Replicon chromosome
Accession NZ_CP043386
Organism Staphylococcus aureus strain NRS384

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag FZC49_RS04375 Protein ID WP_000052078.1
Coordinates 888882..889070 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FZC49_RS04380 Protein ID WP_001059690.1
Coordinates 889099..889359 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZC49_RS04345 884923..885393 + 471 WP_000824472.1 hypothetical protein -
FZC49_RS04350 885734..886420 + 687 WP_001548082.1 thermonuclease family protein -
FZC49_RS04355 886777..886977 + 201 WP_001059082.1 cold-shock protein -
FZC49_RS04360 887473..887691 - 219 WP_000005886.1 hypothetical protein -
FZC49_RS04365 887753..888037 - 285 WP_001004395.1 hypothetical protein -
FZC49_RS04370 888125..888694 - 570 WP_001106654.1 hypothetical protein -
FZC49_RS04375 888882..889070 - 189 WP_000052078.1 hypothetical protein Toxin
FZC49_RS04380 889099..889359 - 261 WP_001059690.1 hypothetical protein Antitoxin
FZC49_RS04385 889700..889903 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FZC49_RS04390 889900..890136 - 237 WP_000368687.1 hypothetical protein -
FZC49_RS04395 890361..890942 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
FZC49_RS04400 891015..891632 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FZC49_RS04405 891787..892281 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FZC49_RS04410 892680..893102 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FZC49_RS04415 893250..893966 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 883566..914648 31082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T138572 WP_000052078.1 NZ_CP043386:c889070-888882 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T138572 NZ_CP058157:3586523-3586741 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACGATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT138572 WP_001059690.1 NZ_CP043386:c889359-889099 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT138572 NZ_CP058157:3586120-3586494 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References