Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4674886..4675625 Replicon chromosome
Accession NZ_CP043382
Organism Enterobacter hormaechei subsp. xiangfangensis strain WCHEX045001

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag EKN98_RS22815 Protein ID WP_032609220.1
Coordinates 4675140..4675625 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag EKN98_RS22810 Protein ID WP_003857131.1
Coordinates 4674886..4675152 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKN98_RS22790 4670362..4671348 + 987 WP_003857123.1 DUF979 domain-containing protein -
EKN98_RS22795 4671358..4672353 + 996 WP_042863494.1 DUF2891 domain-containing protein -
EKN98_RS22800 4672375..4673763 - 1389 WP_032609222.1 MFS transporter -
EKN98_RS22805 4673893..4674822 + 930 WP_032609221.1 LysR family transcriptional regulator -
EKN98_RS22810 4674886..4675152 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
EKN98_RS22815 4675140..4675625 + 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
EKN98_RS22820 4675999..4676478 + 480 WP_001542736.1 hypothetical protein -
EKN98_RS22825 4676500..4677303 + 804 WP_000619352.1 TIGR02391 family protein -
EKN98_RS22830 4677324..4678757 + 1434 WP_042863492.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T138571 WP_032609220.1 NZ_CP043382:4675140-4675625 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T138571 NZ_CP058157:2371939-2372424 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTACTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTAGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACCA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT138571 WP_003857131.1 NZ_CP043382:4674886-4675152 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT138571 NZ_CP058157:2371685-2371951 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTCGATGCCCCGGTTGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References