Detailed information of TA system TA138560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2223603..2224210
• Replicon: chromosome
• Accession: NZ_CP043382
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain WCHEX045001

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: EKN98_RS11005
• Protein ID: WP_057979982.1
• Coordinates: 2224025..2224210 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EKN98_RS11000
• Protein ID: WP_023315016.1
• Coordinates: 2223603..2224010 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKN98_RS10985	2220346..2221599	+	1254	WP_015572749.1	valine--pyruvate transaminase	-
EKN98_RS10990	2221607..2222062	-	456	WP_023323869.1	4Fe-4S dicluster domain-containing protein	-
EKN98_RS10995	2222523..2223599	+	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
EKN98_RS11000	2223603..2224010	-	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EKN98_RS11005	2224025..2224210	-	186	WP_057979982.1	type II toxin-antitoxin system HicA family toxin	Toxin
EKN98_RS11010	2224460..2225998	-	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
EKN98_RS11015	2226165..2227049	+	885	WP_003860164.1	ROK family protein	-
EKN98_RS11020	2227053..2228891	-	1839	WP_023323871.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T138560 WP_057979982.1 NZ_CP043382:c2224210-2224025 [Enterobacter hormaechei subsp. xiangfangensis]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T138560 NZ_CP058153:c2885303-2884950 [Enterobacter hormaechei]
GTGTGGGCGATTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTATTGCGGGAAAAGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAATTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCAATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGATCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAGAGGAATTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT138560 WP_023315016.1 NZ_CP043382:c2224010-2223603 [Enterobacter hormaechei subsp. xiangfangensis]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT138560 NZ_CP043382:c2224010-2223603 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGTGGTTTCTTTCCTGACGTTCCGGGGTGTTTTTT
TGCGGGGGATTCACTGGATGATGCTTTTCAGGATGCACGTGATGCATTAACTGCCCATTTTGAAGCGTTGTTTGAAATGG
ATGAAATGTTGCCACTTCCGGGTATGGTTGAAGCGCATCTGGCAAGTCATCCGGAGGATTTCATTGGCGGACAATGGTTG
CTGGTGGATATCAATATGAAACAGTTTGAAGGCAGAGTAGAGCGCATCAATATTACGATACCTCGCCGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCACAATTTACTAACCGAAGTGCTTTTCTTGCAGAGGCAGCACGGCGTGTACTGC
CCCGGTGA

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0