Detailed information of TA system TA138559

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 1761071..1761750
• Replicon: chromosome
• Accession: NZ_CP043382
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain WCHEX045001

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: EKN98_RS08700
• Protein ID: WP_032608412.1
• Coordinates: 1761071..1761412 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: EKN98_RS08705
• Protein ID: WP_020456353.1
• Coordinates: 1761433..1761750 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKN98_RS08665	1756564..1756815	+	252	WP_032608418.1	hypothetical protein	-
EKN98_RS08670	1756888..1757112	+	225	WP_032608417.1	hypothetical protein	-
EKN98_RS08675	1757171..1757419	+	249	WP_032608415.1	bacteriocin immunity protein	-
EKN98_RS08680	1757534..1757905	+	372	WP_032608414.1	hypothetical protein	-
EKN98_RS08685	1757985..1758458	-	474	WP_072163380.1	SymE family type I addiction module toxin	-
EKN98_RS08690	1758759..1759628	+	870	WP_032608413.1	HNH endonuclease	-
EKN98_RS08695	1759809..1760816	-	1008	WP_020456355.1	restriction endonuclease	-
EKN98_RS08700	1761071..1761412	-	342	WP_032608412.1	TA system toxin CbtA family protein	Toxin
EKN98_RS08705	1761433..1761750	-	318	WP_020456353.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EKN98_RS08710	1761768..1761989	-	222	WP_032608411.1	DUF987 domain-containing protein	-
EKN98_RS08715	1761998..1762477	-	480	WP_020456351.1	DNA repair protein RadC	-
EKN98_RS08720	1762520..1762738	-	219	WP_020456350.1	hypothetical protein	-
EKN98_RS08725	1762748..1763206	-	459	WP_032608410.1	antirestriction protein	-
EKN98_RS08730	1763312..1763512	-	201	WP_050596949.1	DUF905 family protein	-
EKN98_RS08735	1763640..1764506	-	867	WP_032608409.1	hypothetical protein	-
EKN98_RS08740	1764745..1765428	-	684	WP_020456346.1	DeoR family transcriptional regulator	-
EKN98_RS08745	1765637..1766461	-	825	Protein_1690	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	fosA	-	1752659..1794977	42318

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12747.73 Da
• Isoelectric Point: 9.0060

>T138559 WP_032608412.1 NZ_CP043382:c1761412-1761071 [Enterobacter hormaechei subsp. xiangfangensis]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T138559 NZ_CP058153:c2692800-2692697 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11846.39 Da
• Isoelectric Point: 5.5403

>AT138559 WP_020456353.1 NZ_CP043382:c1761750-1761433 [Enterobacter hormaechei subsp. xiangfangensis]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR

Nucleotide

• Length: 318 bp

>AT138559 NZ_CP043382:c1761750-1761433 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA