Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1215401..1216021 Replicon chromosome
Accession NZ_CP043382
Organism Enterobacter hormaechei subsp. xiangfangensis strain WCHEX045001

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag EKN98_RS06070 Protein ID WP_015571250.1
Coordinates 1215803..1216021 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag EKN98_RS06065 Protein ID WP_006809850.1
Coordinates 1215401..1215775 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKN98_RS06055 1210528..1211721 + 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EKN98_RS06060 1211744..1214890 + 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
EKN98_RS06065 1215401..1215775 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
EKN98_RS06070 1215803..1216021 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
EKN98_RS06075 1216230..1216781 + 552 WP_022650496.1 maltose O-acetyltransferase -
EKN98_RS06080 1216898..1217365 + 468 WP_022650495.1 hypothetical protein -
EKN98_RS06085 1217337..1218797 - 1461 WP_032608667.1 PLP-dependent aminotransferase family protein -
EKN98_RS06090 1218899..1219609 + 711 WP_022650493.1 GNAT family N-acetyltransferase -
EKN98_RS06095 1219606..1219746 - 141 WP_032608666.1 type B 50S ribosomal protein L36 -
EKN98_RS06100 1219749..1220009 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T138558 WP_015571250.1 NZ_CP043382:1215803-1216021 [Enterobacter hormaechei subsp. xiangfangensis]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T138558 NZ_CP043382:1215803-1216021 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTCTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT138558 WP_006809850.1 NZ_CP043382:1215401-1215775 [Enterobacter hormaechei subsp. xiangfangensis]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT138558 NZ_CP058153:c2286061-2285795 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTATGCCGAGTTCATTGACATGCTCGATGCCCCGGTCGCGAACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References