Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4856480..4856996 Replicon chromosome
Accession NZ_CP043378
Organism Klebsiella pneumoniae strain WCHKP095005

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag B7D44_RS23750 Protein ID WP_009486548.1
Coordinates 4856480..4856764 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag B7D44_RS23755 Protein ID WP_002886901.1
Coordinates 4856754..4856996 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D44_RS23725 (4851897) 4851897..4852160 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
B7D44_RS23730 (4852290) 4852290..4852463 + 174 WP_032433782.1 hypothetical protein -
B7D44_RS23735 (4852466) 4852466..4853209 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
B7D44_RS23740 (4853566) 4853566..4855704 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
B7D44_RS23745 (4856012) 4856012..4856476 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
B7D44_RS23750 (4856480) 4856480..4856764 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7D44_RS23755 (4856754) 4856754..4856996 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B7D44_RS23760 (4857074) 4857074..4858984 - 1911 WP_009486549.1 PRD domain-containing protein -
B7D44_RS23765 (4859007) 4859007..4860161 - 1155 WP_002886900.1 lactonase family protein -
B7D44_RS23770 (4860228) 4860228..4860968 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T138553 WP_009486548.1 NZ_CP043378:c4856764-4856480 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T138553 NZ_CP058153:c328292-327990 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT138553 WP_002886901.1 NZ_CP043378:c4856996-4856754 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT138553 NZ_CP058153:c327983-327696 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAAACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References