Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4118677..4119296 Replicon chromosome
Accession NZ_CP043378
Organism Klebsiella pneumoniae strain WCHKP095005

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag B7D44_RS20285 Protein ID WP_002892050.1
Coordinates 4119078..4119296 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag B7D44_RS20280 Protein ID WP_002892066.1
Coordinates 4118677..4119051 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D44_RS20270 (4113829) 4113829..4115022 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
B7D44_RS20275 (4115045) 4115045..4118191 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
B7D44_RS20280 (4118677) 4118677..4119051 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
B7D44_RS20285 (4119078) 4119078..4119296 + 219 WP_002892050.1 HHA domain-containing protein Toxin
B7D44_RS20290 (4119459) 4119459..4120025 + 567 WP_002892030.1 maltose O-acetyltransferase -
B7D44_RS20295 (4119997) 4119997..4120137 - 141 WP_004147370.1 hypothetical protein -
B7D44_RS20300 (4120158) 4120158..4120628 + 471 WP_020802585.1 YlaC family protein -
B7D44_RS20305 (4120603) 4120603..4122054 - 1452 WP_094716440.1 PLP-dependent aminotransferase family protein -
B7D44_RS20310 (4122155) 4122155..4122853 + 699 WP_023287311.1 GNAT family protein -
B7D44_RS20315 (4122850) 4122850..4122990 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
B7D44_RS20320 (4122990) 4122990..4123253 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T138551 WP_002892050.1 NZ_CP043378:4119078-4119296 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T138551 NZ_CP058153:c101421-101101 [Enterobacter hormaechei]
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGACTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCGGGAGTGAATTTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCCTGGATAACATCTTTGGATGTTCATCGGGTACAGTTCAACCTTGGGTTGAAACGCTCATA
A

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT138551 WP_002892066.1 NZ_CP043378:4118677-4119051 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT138551 NZ_CP058153:c101820-101455 [Enterobacter hormaechei]
ATGCAGTCGACCACCTTATCCGGCACATCGGCGGAGAACGCATCCTGCCTTCAGTGGGGTTTAAAACGTAATATCACGCC
ATGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
TTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGACTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTTTAACTAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References