Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833836..834493 Replicon chromosome
Accession NZ_CP043378
Organism Klebsiella pneumoniae strain WCHKP095005

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag B7D44_RS04180 Protein ID WP_002916310.1
Coordinates 834083..834493 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag B7D44_RS04175 Protein ID WP_002916312.1
Coordinates 833836..834102 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D44_RS04150 (828992) 828992..830425 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
B7D44_RS04155 (830544) 830544..831272 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
B7D44_RS04160 (831322) 831322..831633 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
B7D44_RS04165 (831797) 831797..832456 + 660 WP_002916317.1 hemolysin III family protein -
B7D44_RS04170 (832607) 832607..833590 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
B7D44_RS04175 (833836) 833836..834102 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
B7D44_RS04180 (834083) 834083..834493 + 411 WP_002916310.1 protein YgfX Toxin
B7D44_RS04185 (834500) 834500..835021 - 522 WP_004144730.1 flavodoxin FldB -
B7D44_RS04190 (835122) 835122..836018 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
B7D44_RS04195 (836041) 836041..836754 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B7D44_RS04200 (836760) 836760..838493 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T138539 WP_002916310.1 NZ_CP043378:834083-834493 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T138539 NZ_CP058149:c1216603-1216292 [Enterobacter hormaechei]
ATGCCCGCAGTCTCAAGAGCGCCTTTCGACGCGGCCACCAGACATTTTCCTATTCAAGAACTCGCTCTGGAAGATCTTTA
CTGGGTACTAAAAGGAGAGCACTACCCATCACCAGACGACATGCGAAAGCGCTTCCCCAGCCGGGAGAGGATGAAATACC
GGGAAAAATGGTGGGTCATTGACGTAGGTGGCGGGTATTTAAGAGTAATGTTATTTACTGATTTTGAGCGCGGAAAGCTC
TTCATCAAACACACCAGCACTCACGCAGATTATGACAAGCTCACGGACCTCTACCGGAGAAAGAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT138539 WP_002916312.1 NZ_CP043378:833836-834102 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138539 NZ_CP058149:c1216295-1215876 [Enterobacter hormaechei]
ATGAACTTTTCAGCAGCCATCAAAGCGGCAAACGATCTAACAAGGGAGCTCCCTTTCCTGGGCTCAAGCCCGTCGCGACA
AGATTATGAGGATGCTATGGGGTTGGTGGAGTATCTAATTGAGCATGACCCCGATAGTCCGCTGGTAGAGATGCTCACCG
CTAAAATCGATAAATACGAAAACGAGTCTCCGGAGTTTGCAGAATTTAACGCGCGTGTTGCCAGCATTCCGTCAGGCGTT
GCGTTATTGCGAACGCTGATGGATCAGTACCATCTCACTCAGAGCGATTTCGAAAACGAAATAGGTAAGAAGTCTCTGGT
GAGTCGGATCCTCAACGGACAGCGCACGTTAACGCTGGATCATATGCGCGCGCTGGCGAAGCGTTTTGGCGTGCAGGTAA
GTGCATTTGTGGGGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References