Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4605042..4605558 Replicon chromosome
Accession NZ_CP043362
Organism Klebsiella pneumoniae strain WCHKP085104

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag B7D52_RS22375 Protein ID WP_002886902.1
Coordinates 4605042..4605326 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag B7D52_RS22380 Protein ID WP_002886901.1
Coordinates 4605316..4605558 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D52_RS22350 (4600458) 4600458..4600721 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
B7D52_RS22355 (4600851) 4600851..4601024 + 174 WP_032408826.1 hypothetical protein -
B7D52_RS22360 (4601027) 4601027..4601770 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
B7D52_RS22365 (4602127) 4602127..4604265 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
B7D52_RS22370 (4604574) 4604574..4605038 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
B7D52_RS22375 (4605042) 4605042..4605326 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7D52_RS22380 (4605316) 4605316..4605558 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B7D52_RS22385 (4605636) 4605636..4607546 - 1911 WP_009486549.1 PRD domain-containing protein -
B7D52_RS22390 (4607569) 4607569..4608723 - 1155 WP_009309312.1 lactonase family protein -
B7D52_RS22395 (4608790) 4608790..4609530 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T138531 WP_002886902.1 NZ_CP043362:c4605326-4605042 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T138531 NZ_CP058146:c1258174-1257863 [Enterobacter hormaechei]
ATGCCCGCAGTCTCAAGAGCGCCTTTCGACGCGGCCACCAGACATTTTCCTATTCAAGAACTCGCTCTGGAAGATCTTTA
CTGGGTACTAAAAGGAGAGCACTACCCATCACCAGACGACATGCGAAAGCGCTTCCCCAGCCGGGAGAGGATGAAATACC
GGGAAAAATGGTGGGTCATTGACGTAGGTGGCGGGTATTTAAGAGTAATGTTATTTACTGATTTTGAGCGCGGAAAGCTC
TTCATCAAACACACCAGCACTCACGCAGATTATGACAAGCTCACGGACCTCTACCGGAGAAAGAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT138531 WP_002886901.1 NZ_CP043362:c4605558-4605316 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT138531 NZ_CP058146:c1257866-1257447 [Enterobacter hormaechei]
ATGAACTTTTCAGCAGCCATCAAAGCGGCAAACGATCTAACAAGGGAGCTCCCTTTCCTGGGCTCAAGCCCGTCGCGACA
AGATTATGAGGATGCTATGGGGTTGGTGGAGTATCTAATTGAGCATGACCCCGATAGTCCGCTGGTAGAGATGCTCACCG
CTAAAATCGATAAATACGAAAACGAGTCTCCGGAGTTTGCAGAATTTAACGCGCGTGTTGCCAGCATTCCGTCAGGCGTT
GCGTTATTGCGAACGCTGATGGATCAGTACCATCTCACTCAGAGCGATTTCGAAAACGAAATAGGTAAGAAGTCTCTGGT
GAGTCGGATCCTCAACGGACAGCGCACGTTAACGCTGGATCATATGCGCGCGCTGGCGAAGCGTTTTGGCGTGCAGGTAA
GTGCATTTGTGGGGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References