Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801816..802473 Replicon chromosome
Accession NZ_CP043362
Organism Klebsiella pneumoniae strain WCHKP085104

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag B7D52_RS03995 Protein ID WP_002916310.1
Coordinates 802063..802473 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag B7D52_RS03990 Protein ID WP_002916312.1
Coordinates 801816..802082 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D52_RS03965 (797024) 797024..798457 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
B7D52_RS03970 (798576) 798576..799304 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
B7D52_RS03975 (799354) 799354..799665 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
B7D52_RS03980 (799829) 799829..800488 + 660 WP_002916317.1 hemolysin III family protein -
B7D52_RS03985 (800587) 800587..801570 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
B7D52_RS03990 (801816) 801816..802082 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
B7D52_RS03995 (802063) 802063..802473 + 411 WP_002916310.1 protein YgfX Toxin
B7D52_RS04000 (802480) 802480..803001 - 522 WP_004144730.1 flavodoxin FldB -
B7D52_RS04005 (803102) 803102..803998 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
B7D52_RS04010 (804021) 804021..804734 + 714 WP_071081169.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B7D52_RS04015 (804740) 804740..806473 + 1734 WP_071081170.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T138519 WP_002916310.1 NZ_CP043362:802063-802473 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T138519 NZ_CP043362:802063-802473 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT138519 WP_002916312.1 NZ_CP043362:801816-802082 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138519 NZ_CP058131:c3865154-3864867 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGTTGCGTTCGATGC
GCAAGAACGTCAGCACCGATTACGTACTATGCTGGCACAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTTGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCACCAGCCTGGATACCTTAACGCGA
TACGCGTTAGCGTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References