Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 158987..159732 | Replicon | plasmid p1_020120 |
| Accession | NZ_CP043359 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020120 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A331KSM6 |
| Locus tag | CLQ78_RS28735 | Protein ID | WP_032408901.1 |
| Coordinates | 159241..159732 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | CLQ78_RS28730 | Protein ID | WP_014386183.1 |
| Coordinates | 158987..159253 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CLQ78_RS28680 (CLQ78_28660) | 154539..154952 | - | 414 | WP_013023817.1 | helix-turn-helix domain-containing protein | - |
| CLQ78_RS28685 (CLQ78_28665) | 154953..155231 | - | 279 | WP_004152721.1 | helix-turn-helix transcriptional regulator | - |
| CLQ78_RS28690 (CLQ78_28670) | 155221..155541 | - | 321 | WP_014386190.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| CLQ78_RS28695 (CLQ78_28675) | 155622..155846 | - | 225 | WP_014386189.1 | hypothetical protein | - |
| CLQ78_RS28700 (CLQ78_28680) | 155857..156069 | - | 213 | WP_014386188.1 | hypothetical protein | - |
| CLQ78_RS28705 (CLQ78_28685) | 156131..156457 | - | 327 | WP_014386187.1 | hypothetical protein | - |
| CLQ78_RS28710 (CLQ78_28690) | 157094..157444 | - | 351 | WP_014386186.1 | hypothetical protein | - |
| CLQ78_RS28715 (CLQ78_28695) | 157441..157713 | - | 273 | WP_032408902.1 | hypothetical protein | - |
| CLQ78_RS28720 (CLQ78_28700) | 157903..158388 | + | 486 | WP_014386185.1 | hypothetical protein | - |
| CLQ78_RS28725 (CLQ78_28705) | 158632..158790 | - | 159 | WP_014386184.1 | type I toxin-antitoxin system Hok family toxin | - |
| CLQ78_RS28730 (CLQ78_28710) | 158987..159253 | + | 267 | WP_014386183.1 | DUF1778 domain-containing protein | Antitoxin |
| CLQ78_RS28735 (CLQ78_28715) | 159241..159732 | + | 492 | WP_032408901.1 | GNAT family N-acetyltransferase | Toxin |
| CLQ78_RS28740 (CLQ78_28720) | 160173..160424 | - | 252 | WP_032408900.1 | aldo/keto reductase | - |
| CLQ78_RS28745 (CLQ78_28725) | 160621..162213 | - | 1593 | Protein_179 | IS66 family transposase | - |
| CLQ78_RS28750 (CLQ78_28730) | 162244..162594 | - | 351 | WP_014386180.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CLQ78_RS28755 (CLQ78_28735) | 162591..163031 | - | 441 | WP_014386179.1 | transposase | - |
| CLQ78_RS28760 (CLQ78_28740) | 163293..164048 | - | 756 | WP_032408898.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / dfrA12 / aadA2 / qacE / sul1 / mph(A) | - | 1..205652 | 205652 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17667.46 Da Isoelectric Point: 8.8757
>T138513 WP_032408901.1 NZ_CP043359:159241-159732 [Klebsiella pneumoniae subsp. pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
Download Length: 492 bp
>T138513 NZ_CP043359:159241-159732 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10090.66 Da Isoelectric Point: 5.1169
>AT138513 WP_014386183.1 NZ_CP043359:158987-159253 [Klebsiella pneumoniae subsp. pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
Download Length: 267 bp
>AT138513 NZ_CP058128:c4782218-4781976 [Enterobacter hormaechei]
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|