Detailed information of TA system TA138503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4903875..4904391
• Replicon: chromosome
• Accession: NZ_CP043357
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020120

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J2XDK6
• Locus tag: CLQ78_RS24200
• Protein ID: WP_002886902.1
• Coordinates: 4903875..4904159 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: CLQ78_RS24205
• Protein ID: WP_002886901.1
• Coordinates: 4904149..4904391 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLQ78_RS24175 (CLQ78_24160)	4899359..4899622	-	264	WP_004152271.1	PTS sugar transporter subunit IIB	-
CLQ78_RS24180 (CLQ78_24165)	4899752..4899925	+	174	WP_002886906.1	hypothetical protein	-
CLQ78_RS24185 (CLQ78_24170)	4899928..4900671	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
CLQ78_RS24190 (CLQ78_24175)	4901028..4903166	+	2139	WP_002886904.1	anaerobic ribonucleoside-triphosphate reductase	-
CLQ78_RS24195 (CLQ78_24180)	4903407..4903871	+	465	WP_002886903.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
CLQ78_RS24200 (CLQ78_24185)	4903875..4904159	-	285	WP_002886902.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CLQ78_RS24205 (CLQ78_24190)	4904149..4904391	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CLQ78_RS24210 (CLQ78_24195)	4904469..4906379	-	1911	WP_004152270.1	PRD domain-containing protein	-
CLQ78_RS24215 (CLQ78_24200)	4906402..4907556	-	1155	WP_002886900.1	lactonase family protein	-
CLQ78_RS24220 (CLQ78_24205)	4907622..4908362	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11125.95 Da
• Isoelectric Point: 10.3787

>T138503 WP_002886902.1 NZ_CP043357:c4904159-4903875 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T138503 NZ_CP058119:c121210-120728 [Klebsiella michiganensis]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT138503 WP_002886901.1 NZ_CP043357:c4904391-4904149 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT138503 NZ_CP043357:c4904391-4904149 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0H3GMH2

Antitoxin

• AlphaFold DB: A0A0H3GLP0