Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878699..879353 Replicon chromosome
Accession NZ_CP043357
Organism Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020120

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag CLQ78_RS04425 Protein ID WP_004144731.1
Coordinates 878946..879353 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CLQ78_RS04420 Protein ID WP_002916312.1
Coordinates 878699..878965 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ78_RS04395 (CLQ78_04395) 873855..875288 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
CLQ78_RS04400 (CLQ78_04400) 875407..876135 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CLQ78_RS04405 (CLQ78_04405) 876185..876496 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
CLQ78_RS04410 (CLQ78_04410) 876660..877319 + 660 WP_002916317.1 hemolysin III family protein -
CLQ78_RS04415 (CLQ78_04415) 877470..878453 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CLQ78_RS04420 (CLQ78_04420) 878699..878965 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CLQ78_RS04425 (CLQ78_04425) 878946..879353 + 408 WP_004144731.1 protein YgfX Toxin
CLQ78_RS04430 (CLQ78_04430) 879360..879881 - 522 WP_002916308.1 flavodoxin FldB -
CLQ78_RS04435 (CLQ78_04435) 879982..880878 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CLQ78_RS04440 (CLQ78_04440) 880901..881614 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CLQ78_RS04445 (CLQ78_04445) 881620..883353 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T138491 WP_004144731.1 NZ_CP043357:878946-879353 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T138491 NZ_CP043357:878946-879353 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT138491 WP_002916312.1 NZ_CP043357:878699-878965 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138491 NZ_CP043357:878699-878965 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References