Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4650046..4650738 Replicon chromosome
Accession NZ_CP043348
Organism Klebsiella pneumoniae strain WCHKP020097

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag CAY71_RS22600 Protein ID WP_045411008.1
Coordinates 4650046..4650387 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CAY71_RS22605 Protein ID WP_040189932.1
Coordinates 4650412..4650738 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAY71_RS22575 (4645935) 4645935..4647389 - 1455 WP_087497896.1 serine protease -
CAY71_RS22580 (4647577) 4647577..4648374 - 798 WP_045411004.1 helix-turn-helix transcriptional regulator -
CAY71_RS22585 (4648494) 4648494..4648769 - 276 WP_087497895.1 type II toxin-antitoxin system RelE/ParE family toxin -
CAY71_RS22590 (4648773) 4648773..4649021 - 249 WP_000535212.1 ribbon-helix-helix domain-containing protein -
CAY71_RS22595 (4649098) 4649098..4649931 - 834 WP_045411133.1 DUF4942 domain-containing protein -
CAY71_RS22600 (4650046) 4650046..4650387 - 342 WP_045411008.1 TA system toxin CbtA family protein Toxin
CAY71_RS22605 (4650412) 4650412..4650738 - 327 WP_040189932.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CAY71_RS22610 (4650752) 4650752..4651228 - 477 WP_045411015.1 DNA repair protein RadC -
CAY71_RS22615 (4651239) 4651239..4651685 - 447 WP_045411016.1 antirestriction protein -
CAY71_RS22620 (4651909) 4651909..4652598 - 690 WP_045411017.1 hypothetical protein -
CAY71_RS22625 (4652918) 4652918..4653271 + 354 WP_087497894.1 hypothetical protein -
CAY71_RS22630 (4653308) 4653308..4654198 - 891 WP_087497893.1 YfjP family GTPase -
CAY71_RS22635 (4654281) 4654281..4655369 - 1089 WP_087497892.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12730.63 Da        Isoelectric Point: 7.8846

>T138458 WP_045411008.1 NZ_CP043348:c4650387-4650046 [Klebsiella pneumoniae]
MKTIPATTQRAAKSCPSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETAIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQVTGLLRQSPHPSIR

Download         Length: 342 bp

>T138458 NZ_CP057918:3128544-3128762 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12333.06 Da        Isoelectric Point: 6.9560

>AT138458 WP_040189932.1 NZ_CP043348:c4650738-4650412 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDAECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp

>AT138458 NZ_CP043348:c4650738-4650412 [Klebsiella pneumoniae]
ATGCCACTGACTGATGCCATACAGTGGGGATTAAAGCGAAGTTTCACACCGAATTTTGGCGCAAGGCTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAATATCACCGGTAAATTTGTTGATGCCGAATGTCAGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTTAATCCCCGTCATGCGCACAGCGTCACT
CTCTACCACAACGCTTTCACCTGTGAAGCCGATACTCTCGGCAGTTGTGGTTACGTCTACATCGTTATTTATCCCACTCA
ACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References