Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3984661..3985280 Replicon chromosome
Accession NZ_CP043348
Organism Klebsiella pneumoniae strain WCHKP020097

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CAY71_RS19365 Protein ID WP_002892050.1
Coordinates 3985062..3985280 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag CAY71_RS19360 Protein ID WP_080789174.1
Coordinates 3984661..3985035 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAY71_RS19350 (3979813) 3979813..3981006 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CAY71_RS19355 (3981029) 3981029..3984175 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
CAY71_RS19360 (3984661) 3984661..3985035 + 375 WP_080789174.1 Hha toxicity modulator TomB Antitoxin
CAY71_RS19365 (3985062) 3985062..3985280 + 219 WP_002892050.1 HHA domain-containing protein Toxin
CAY71_RS19370 (3985439) 3985439..3986005 + 567 WP_002892030.1 maltose O-acetyltransferase -
CAY71_RS19375 (3985977) 3985977..3986117 - 141 WP_004147370.1 hypothetical protein -
CAY71_RS19380 (3986138) 3986138..3986608 + 471 WP_002892026.1 YlaC family protein -
CAY71_RS19385 (3986583) 3986583..3988033 - 1451 Protein_3808 PLP-dependent aminotransferase family protein -
CAY71_RS19390 (3988134) 3988134..3988832 + 699 WP_002892021.1 GNAT family protein -
CAY71_RS19395 (3988829) 3988829..3988969 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
CAY71_RS19400 (3988969) 3988969..3989232 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T138456 WP_002892050.1 NZ_CP043348:3985062-3985280 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T138456 NZ_CP057918:1821149-1821252 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14295.99 Da        Isoelectric Point: 5.1444

>AT138456 WP_080789174.1 NZ_CP043348:3984661-3985035 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAGDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT138456 NZ_CP057918:c1821290-1821022 [Escherichia fergusonii]
AAAGTCAGCGAATGGAATATTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References