Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4834732..4835248 Replicon chromosome
Accession NZ_CP043344
Organism Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020039

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag CVC44_RS23760 Protein ID WP_002886902.1
Coordinates 4834732..4835016 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CVC44_RS23765 Protein ID WP_002886901.1
Coordinates 4835006..4835248 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVC44_RS23735 (CVC44_23930) 4830216..4830479 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
CVC44_RS23740 4830609..4830782 + 174 WP_002886906.1 hypothetical protein -
CVC44_RS23745 (CVC44_23935) 4830785..4831528 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CVC44_RS23750 (CVC44_23940) 4831885..4834023 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
CVC44_RS23755 (CVC44_23945) 4834264..4834728 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CVC44_RS23760 (CVC44_23950) 4834732..4835016 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CVC44_RS23765 (CVC44_23955) 4835006..4835248 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CVC44_RS23770 (CVC44_23960) 4835326..4837236 - 1911 WP_004152270.1 PRD domain-containing protein -
CVC44_RS23775 (CVC44_23965) 4837259..4838413 - 1155 WP_002886900.1 lactonase family protein -
CVC44_RS23780 (CVC44_23970) 4838479..4839219 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T138436 WP_002886902.1 NZ_CP043344:c4835016-4834732 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T138436 NZ_CP057864:2033857-2033960 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT138436 WP_002886901.1 NZ_CP043344:c4835248-4835006 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT138436 NZ_CP043344:c4835248-4835006 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References