Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878740..879394 Replicon chromosome
Accession NZ_CP043344
Organism Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020039

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag CVC44_RS04430 Protein ID WP_004144731.1
Coordinates 878987..879394 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CVC44_RS04425 Protein ID WP_002916312.1
Coordinates 878740..879006 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVC44_RS04400 (CVC44_04435) 873896..875329 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
CVC44_RS04405 (CVC44_04440) 875448..876176 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CVC44_RS04410 (CVC44_04445) 876226..876537 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
CVC44_RS04415 (CVC44_04450) 876701..877360 + 660 WP_002916317.1 hemolysin III family protein -
CVC44_RS04420 (CVC44_04455) 877511..878494 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CVC44_RS04425 (CVC44_04460) 878740..879006 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CVC44_RS04430 (CVC44_04465) 878987..879394 + 408 WP_004144731.1 protein YgfX Toxin
CVC44_RS04435 (CVC44_04470) 879401..879922 - 522 WP_002916308.1 flavodoxin FldB -
CVC44_RS04440 (CVC44_04475) 880023..880919 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CVC44_RS04445 (CVC44_04480) 880942..881655 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CVC44_RS04450 (CVC44_04485) 881661..883394 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T138424 WP_004144731.1 NZ_CP043344:878987-879394 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T138424 NZ_CP057722:3861833-3862051 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT138424 WP_002916312.1 NZ_CP043344:878740-879006 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138424 NZ_CP057722:3861432-3861806 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References