Detailed information of TA system TA138406

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 866702..867359
• Replicon: chromosome
• Accession: NZ_CP043342
• Organism: Enterobacter huaxiensis strain 090008 = WCHEHu090008

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: D5067_RS04230
• Protein ID: WP_119936144.1
• Coordinates: 866949..867359 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V3PWU7
• Locus tag: D5067_RS04225
• Protein ID: WP_010435322.1
• Coordinates: 866702..866968 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5067_RS04200 (D5067_0004225)	861843..863276	-	1434	WP_119936149.1	6-phospho-beta-glucosidase	-
D5067_RS04205 (D5067_0004230)	863393..864124	-	732	WP_119936148.1	MurR/RpiR family transcriptional regulator	-
D5067_RS04210 (D5067_0004235)	864175..864486	+	312	WP_119936147.1	N(4)-acetylcytidine aminohydrolase	-
D5067_RS04215 (D5067_0004240)	864651..865310	+	660	WP_119936146.1	hemolysin III family protein	-
D5067_RS04220 (D5067_0004245)	865430..866410	-	981	WP_119936145.1	tRNA-modifying protein YgfZ	-
D5067_RS04225 (D5067_0004250)	866702..866968	+	267	WP_010435322.1	FAD assembly factor SdhE	Antitoxin
D5067_RS04230 (D5067_0004255)	866949..867359	+	411	WP_119936144.1	protein YgfX	Toxin
D5067_RS04235 (D5067_0004260)	867367..867888	-	522	WP_119936143.1	flavodoxin FldB	-
D5067_RS04240 (D5067_0004265)	867990..868886	+	897	WP_119936142.1	site-specific tyrosine recombinase XerD	-
D5067_RS04245 (D5067_0004270)	868915..869628	+	714	WP_119936141.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
D5067_RS04250 (D5067_0004275)	869634..871367	+	1734	WP_119936140.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16171.07 Da
• Isoelectric Point: 11.5020

>T138406 WP_119936144.1 NZ_CP043342:866949-867359 [Enterobacter huaxiensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEIIGTPWMLSAGMMLRLRQLEGGRRQHLWLAADSMDAAEWRELRRMILQQPTQD

Nucleotide

• Length: 411 bp

>T138406 NZ_CP057692:1617985-1618203 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1340

>AT138406 WP_010435322.1 NZ_CP043342:866702-866968 [Enterobacter huaxiensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT138406 NZ_CP043342:866702-866968 [Enterobacter huaxiensis]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGACGATAAGCGTCTGTTTGTTCGCCTGCTAGAGTCTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: V3PWU7