Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3551801..3552419 Replicon chromosome
Accession NZ_CP043334
Organism Escherichia coli strain WCHEC115106

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FZC46_RS17270 Protein ID WP_001291435.1
Coordinates 3552201..3552419 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag FZC46_RS17265 Protein ID WP_000344800.1
Coordinates 3551801..3552175 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZC46_RS17255 (3546890) 3546890..3548083 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FZC46_RS17260 (3548106) 3548106..3551255 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
FZC46_RS17265 (3551801) 3551801..3552175 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
FZC46_RS17270 (3552201) 3552201..3552419 + 219 WP_001291435.1 HHA domain-containing protein Toxin
FZC46_RS17275 (3552591) 3552591..3553142 + 552 WP_000102568.1 maltose O-acetyltransferase -
FZC46_RS17280 (3553258) 3553258..3553728 + 471 WP_000136192.1 YlaC family protein -
FZC46_RS17285 (3553892) 3553892..3555442 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FZC46_RS17290 (3555484) 3555484..3555837 - 354 WP_000878140.1 DUF1428 domain-containing protein -
FZC46_RS17300 (3556216) 3556216..3556527 + 312 WP_000409911.1 MGMT family protein -
FZC46_RS17305 (3556558) 3556558..3557130 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T138391 WP_001291435.1 NZ_CP043334:3552201-3552419 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T138391 NZ_CP057681:c2080738-2080451 [Escherichia fergusonii]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT138391 WP_000344800.1 NZ_CP043334:3551801-3552175 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT138391 NZ_CP057681:c2080464-2080162 [Escherichia fergusonii]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAATAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References