Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2845646..2846490 Replicon chromosome
Accession NZ_CP043334
Organism Escherichia coli strain WCHEC115106

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag FZC46_RS13900 Protein ID WP_000854686.1
Coordinates 2845646..2846029 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag FZC46_RS13905 Protein ID WP_001285602.1
Coordinates 2846110..2846490 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZC46_RS13860 (2840649) 2840649..2841140 - 492 WP_001297187.1 DUF1097 domain-containing protein -
FZC46_RS13865 (2841242) 2841242..2841796 - 555 WP_001001902.1 molecular chaperone YcdY -
FZC46_RS13870 (2841820) 2841820..2842557 - 738 WP_000283664.1 zinc-binding phosphatase -
FZC46_RS13875 (2842612) 2842612..2843550 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
FZC46_RS13885 (2844021) 2844021..2844862 - 842 Protein_2728 DUF4942 domain-containing protein -
FZC46_RS13890 (2844947) 2844947..2845144 - 198 WP_000839253.1 DUF957 domain-containing protein -
FZC46_RS13895 (2845161) 2845161..2845649 - 489 WP_032180032.1 DUF5983 family protein -
FZC46_RS13900 (2845646) 2845646..2846029 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
FZC46_RS13905 (2846110) 2846110..2846490 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FZC46_RS13910 (2846501) 2846501..2847184 - 684 WP_000086768.1 hypothetical protein -
FZC46_RS13915 (2847203) 2847203..2847424 - 222 WP_000692298.1 DUF987 domain-containing protein -
FZC46_RS13920 (2847487) 2847487..2847963 - 477 WP_001186726.1 RadC family protein -
FZC46_RS13925 (2847979) 2847979..2848464 - 486 WP_000214307.1 antirestriction protein -
FZC46_RS13930 (2848556) 2848556..2849377 - 822 WP_001761104.1 DUF932 domain-containing protein -
FZC46_RS13935 (2849478) 2849478..2849686 - 209 Protein_2738 DUF905 family protein -
FZC46_RS13940 (2849787) 2849787..2850242 - 456 WP_000581506.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T138389 WP_000854686.1 NZ_CP043334:c2846029-2845646 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T138389 NZ_CP043334:c2846029-2845646 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT138389 WP_001285602.1 NZ_CP043334:c2846490-2846110 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT138389 NZ_CP057681:c1741302-1741009 [Escherichia fergusonii]
ATGCATCGAATTCTTGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATATTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGTCCATAAAGGCGCGTTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGGCTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References