Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 318968..319554 Replicon chromosome
Accession NZ_CP043334
Organism Escherichia coli strain WCHEC115106

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag FZC46_RS01475 Protein ID WP_042014162.1
Coordinates 318968..319198 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag FZC46_RS01480 Protein ID WP_000593555.1
Coordinates 319195..319554 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZC46_RS01465 (315005) 315005..317740 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
FZC46_RS01470 (317740) 317740..318864 + 1125 WP_001314210.1 ABC transporter permease -
FZC46_RS01475 (318968) 318968..319198 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
FZC46_RS01480 (319195) 319195..319554 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FZC46_RS01485 (319674) 319674..320075 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
FZC46_RS01490 (320081) 320081..320887 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
FZC46_RS01495 (320884) 320884..321648 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
FZC46_RS01500 (321648) 321648..322481 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
FZC46_RS01505 (322478) 322478..323422 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T138371 WP_042014162.1 NZ_CP043334:318968-319198 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T138371 NZ_CP057657:1607707-1607925 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTGTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT138371 WP_000593555.1 NZ_CP043334:319195-319554 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT138371 NZ_CP043334:319195-319554 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References