Detailed information of TA system TA138369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3774760..3775459
• Replicon: chromosome
• Accession: NZ_CP043332
• Organism: Proteus mirabilis strain CRPM10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: FY167_RS17475
• Protein ID: WP_004249093.1
• Coordinates: 3774760..3775146 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: FY167_RS17480
• Protein ID: WP_004246828.1
• Coordinates: 3775139..3775459 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY167_RS17460	3770779..3771360	-	582	WP_149127763.1	DNA-3-methyladenine glycosylase I	-
FY167_RS17465	3771611..3772516	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
FY167_RS17470	3772526..3774598	+	2073	WP_041701373.1	glycine--tRNA ligase subunit beta	-
FY167_RS17475	3774760..3775146	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY167_RS17480	3775139..3775459	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
FY167_RS17485	3775508..3775942	-	435	WP_020946391.1	hypothetical protein	-
FY167_RS17490	3775935..3776819	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
FY167_RS17495	3777034..3778320	-	1287	WP_064506173.1	DUF3748 domain-containing protein	-
FY167_RS17500	3778457..3779074	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
FY167_RS17505	3779376..3779999	+	624	WP_004246821.1	guanylate kinase	-
FY167_RS17510	3780054..3780329	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T138369 WP_004249093.1 NZ_CP043332:3774760-3775146 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T138369 NZ_CP043332:3774760-3775146 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT138369 WP_004246828.1 NZ_CP043332:3775139-3775459 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT138369 NZ_CP043332:3775139-3775459 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGAATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCCGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97