Detailed information of TA system TA138366

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1562673..1563318
• Replicon: chromosome
• Accession: NZ_CP043332
• Organism: Proteus mirabilis strain CRPM10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: FY167_RS07190
• Protein ID: WP_004247035.1
• Coordinates: 1563133..1563318 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: FY167_RS07185
• Protein ID: WP_004247034.1
• Coordinates: 1562673..1563086 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY167_RS19645	1558217..1558375	-	159	WP_004247025.1	hypothetical protein	-
FY167_RS19650	1558828..1559004	+	177	WP_004247793.1	hypothetical protein	-
FY167_RS07155	1559181..1559927	-	747	WP_004247794.1	class I SAM-dependent methyltransferase	-
FY167_RS07165	1560778..1561356	+	579	WP_004247796.1	alpha/beta hydrolase	-
FY167_RS07170	1561469..1561762	-	294	Protein_1363	LysE family transporter	-
FY167_RS07180	1561936..1562577	-	642	WP_149127437.1	response regulator	-
FY167_RS07185	1562673..1563086	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FY167_RS07190	1563133..1563318	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
FY167_RS07195	1563574..1564200	+	627	Protein_1367	DUF1073 domain-containing protein	-
FY167_RS07200	1564757..1565308	-	552	WP_049208654.1	PH domain-containing protein	-
FY167_RS07205	1565412..1565687	-	276	WP_149127438.1	hypothetical protein	-
FY167_RS07210	1566080..1567261	-	1182	WP_074924370.1	phage integrase SAM-like domain-containing protein	-
FY167_RS07215	1567263..1567469	-	207	WP_049219192.1	hypothetical protein	-
FY167_RS07220	1567546..1568022	-	477	WP_149127439.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1562673..1614327	51654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T138366 WP_004247035.1 NZ_CP043332:c1563318-1563133 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T138366 NZ_CP057632:c4697896-4697510 [Citrobacter sp. RHB20-C15]
ATGCAAAAGGGACCCGTGTTGTTCGATACCAATATCCTGATTGATTTATTTAGCGGGCGCCAGGAAGCACAGCAAGTACT
GGAAGCGTATCCGCCGCAGAATGCCATCAGCTTGATTACCTGGATGGAAGTCATGGTGGGGGCAAAAAAATACCATCAGG
AATATCGTACGCGTGTGGCATTGAGTGCGTTCAATATCATCGGTGTATCACTGGAAATTGCTGAGCGAAGCGTGAATCTC
AGGCAGGAATATGGGATGAAACTTCCGGACGCGATCATTCTGGCTACCGCGCAGATTCATCGGTTTGCGCTTGTGACGCG
CAACACCAGAGATTTCGCGGGGATACCTGGCGTCATTACGCCTTATCAGTTGCAGGCCGGACGATAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT138366 WP_004247034.1 NZ_CP043332:c1563086-1562673 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT138366 NZ_CP057632:c4698138-4697896 [Citrobacter sp. RHB20-C15]
ATAATGGCTGGAATGGACATGGGCAGAATATTACTCGACTTATCCGATGAGGTGATCAAACGCCTTGACGATCTCAAGCA
GCAGCGGAATCTGCCCCGTGCGGAGTTGCTGCGCGAAGCGGTTGAACAGTACCTTGAAAGGCAAGGCCAGGCTGAAACCA
CAATTTCCAATGCGCTGGGGCTCTGGCAGGGTTGTGAGGAAGACGGCGTTGAGTATCAGAGGACGCTGCGCGAGGAATGG
TAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85