Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 80860..82458 Replicon chromosome
Accession NZ_CP043332
Organism Proteus mirabilis strain CRPM10

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FY167_RS00410 Protein ID WP_149127271.1
Coordinates 80860..82203 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FY167_RS00415 Protein ID WP_041701484.1
Coordinates 82207..82458 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY167_RS00390 76477..77661 + 1185 WP_004246423.1 multidrug efflux MFS transporter EmrD -
FY167_RS00395 77771..79303 - 1533 WP_004246422.1 glycerol kinase GlpK -
FY167_RS00400 79346..80161 - 816 WP_004246421.1 aquaporin -
FY167_RS00405 80458..80700 + 243 WP_012368679.1 cell division protein ZapB -
FY167_RS00410 80860..82203 - 1344 WP_149127271.1 type II toxin-antitoxin system HipA family toxin Toxin
FY167_RS00415 82207..82458 - 252 WP_041701484.1 helix-turn-helix domain-containing protein Antitoxin
FY167_RS00420 83034..83552 - 519 WP_004246419.1 ribonuclease E activity regulator RraA -
FY167_RS00425 83661..84578 - 918 WP_020946557.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
FY167_RS00430 84677..86017 - 1341 WP_004246417.1 HslU--HslV peptidase ATPase subunit -
FY167_RS00435 86030..86560 - 531 WP_004246416.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49863.30 Da        Isoelectric Point: 5.3203

>T138365 WP_149127271.1 NZ_CP043332:c82203-80860 [Proteus mirabilis]
MKAQILYVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN

Download         Length: 1344 bp

>T138365 NZ_CP057632:c4341037-4340561 [Citrobacter sp. RHB20-C15]
ATGGATTTTCCCACATGGCTGAACGGGTGGACGATCTACGCTCATCCCTGTTTTATCGATCAATACAACGCGCTGGTCGC
ACGTGTTGAAGACCTTAAGCACAGGTTTCCAGATCCCATTGTTTTCCAGAAGAAGAAAGAGACCAAGGTGCTGGCGCATT
TATTGAAATCCATTGCCAACATTACCCACGAACCCCGAGCTTCTGTTTACCGGCCTGGTGACAGTATAGGGAAAGCTTAT
ACAGACTGGTCGAGAGCGAAGTTTGGTGGAGGACGGTATCGCTTATTTTTCCGTTATAGTCTCGAGAGTAAGATCATTGT
CATCGCATGGGTGAATGATGAAGGGCCATTGCGCACCTACGGCAGCAAGACCGATGCCTATAAGATTTTCGGGAAAATGC
TTGATGAGGGGAATCCACCCGACGACTGGCTAAGTTTGCTTCAGGCTTGTCAAAACGACGGGAAGGAACATCTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9390.83 Da        Isoelectric Point: 9.8955

>AT138365 WP_041701484.1 NZ_CP043332:c82458-82207 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Download         Length: 252 bp

>AT138365 NZ_CP043332:c82458-82207 [Proteus mirabilis]
ATGAAAATTACAACGCCATCAATGTTAGCCGCTGCAATACATGACTTGCGCAAACAAAGTAAATTAACCCAAGCTCAAAC
GGCTGAACAAGTCGGTCTCAGGCAAGCAACTGTCTCTGAATTTGAGAACAACCCAGAATCAACAAAACTCGAAACGCTTT
TCAAAATCCTTGCCTCTTTGGAACTGGAACTACATGTAGTGAAGCGAGGAAAAAACCTGAGTGAGGGTAAGGTTTGGAAT
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References