Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 14601..15202 Replicon chromosome
Accession NZ_CP043332
Organism Proteus mirabilis strain CRPM10

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag FY167_RS00065 Protein ID WP_004246497.1
Coordinates 14601..14984 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag FY167_RS00070 Protein ID WP_004246496.1
Coordinates 14981..15202 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY167_RS00040 9974..10432 + 459 WP_004249766.1 GNAT family N-acetyltransferase -
FY167_RS00045 10528..11265 - 738 WP_004249950.1 sel1 repeat family protein -
FY167_RS00050 11374..12273 + 900 WP_149127256.1 N-acetylmuramic acid 6-phosphate etherase -
FY167_RS00055 12630..13868 - 1239 WP_020946511.1 HipA domain-containing protein -
FY167_RS00060 13881..14195 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
FY167_RS00065 14601..14984 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FY167_RS00070 14981..15202 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FY167_RS00075 15424..16287 - 864 WP_004249947.1 YicC family protein -
FY167_RS00080 16414..17130 + 717 WP_004249760.1 ribonuclease PH -
FY167_RS00085 17212..17856 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
FY167_RS00090 18175..18780 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
FY167_RS00095 18900..19358 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T138364 WP_004246497.1 NZ_CP043332:c14984-14601 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T138364 NZ_CP043332:c14984-14601 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT138364 WP_004246496.1 NZ_CP043332:c15202-14981 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT138364 NZ_CP057632:c4126960-4126619 [Citrobacter sp. RHB20-C15]
ATGAAATCTACTGGCTCAGAGAACGATTCATTTCTCCAGTGGGGGCTGAATCGTAATGTGACGCCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGTTGACCGGGCCAGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGAAGTGAATCCTCGGCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References