Detailed information of TA system TA138361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3773749..3774970
• Replicon: chromosome
• Accession: NZ_CP043328
• Organism: Pseudomonas aeruginosa strain CCUG 51971

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: V6AG16
• Locus tag: FZE14_RS18200
• Protein ID: WP_003088107.1
• Coordinates: 3774392..3774970 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FZE14_RS18195
• Protein ID: WP_003088112.1
• Coordinates: 3773749..3774303 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZE14_RS18170	3769317..3769868	+	552	WP_023098678.1	XRE family transcriptional regulator	-
FZE14_RS18175	3769865..3770263	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
FZE14_RS18180	3770276..3770599	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
FZE14_RS18185	3770930..3771391	+	462	WP_003088117.1	(2Fe-2S)-binding protein	-
FZE14_RS18190	3771396..3773591	+	2196	WP_003088114.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
FZE14_RS18195	3773749..3774303	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
FZE14_RS18200	3774392..3774970	+	579	WP_003088107.1	HD domain-containing protein	Toxin
FZE14_RS18205	3775079..3776266	-	1188	WP_003088106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
FZE14_RS18210	3776256..3778427	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-
FZE14_RS18215	3778417..3779694	-	1278	WP_003088104.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-187)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21885.74 Da
• Isoelectric Point: 5.3655

>T138361 WP_003088107.1 NZ_CP043328:3774392-3774970 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T138361 NZ_CP057632:2459894-2460172 [Citrobacter sp. RHB20-C15]
ATGATCATGAATTTCAGGCACAAGGGATTACGCGACCTGTTTCTTCACGGTAAAACGTCAGGCGTGCTGGCAAAGCACGT
CAAACGTTTGCGACACCGCCTCGCCGTGATTGACGCCGCAGGCTGCGTGAACGATATCAACATGCCCGGTTATCGGCTGC
ATCCTCTGAGCGGCGATCGTGATGGCGTCTGGTCAATATCGGTTTCAGGCAACTGGCGTATGACGTTCGAATTCGTCAAT
GGCGATGCGTATATTTTGGATGACGAGGATTATCACTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT138361 WP_003088112.1 NZ_CP043328:3773749-3774303 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT138361 NZ_CP057632:2460172-2460456 [Citrobacter sp. RHB20-C15]
ATGAAAATGGCGAATCATCCCCGCCCAGGGGATATCATTCAGGAAGCGCTGGACGAACTGAACGTCAGTTTGCGTGAATT
TGCCAGAGCAATGGAGATTGCGCCCTCAACCGCCAGCCGGTTACTCACGGGCAAAGCGGCACTCACCCCGGAAATGGCGA
TCAAACTCTCGGTGGTGATCGGCAGCTCCCCGGAGATGTGGCTAAATCTGCAAAATACCTGGAGTCTGGCACAAGCGCAA
AAAAGCGTGGACGTGTCCCGTCTGCGCCGTCTGGCGGTGCAGTAA

Structures

Toxin

• AlphaFold DB: V6AG16