Detailed information of TA system TA138353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1518785..1520424
• Replicon: chromosome
• Accession: NZ_CP043320
• Organism: Pseudomonas sp. C27(2019)

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: FXF61_RS06895
• Protein ID: WP_151184577.1
• Coordinates: 1518785..1520101 (-)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: FXF61_RS06900
• Protein ID: WP_151184578.1
• Coordinates: 1520095..1520424 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXF61_RS06890	1518191..1518565	-	375	WP_178087273.1	helix-turn-helix domain-containing protein	-
FXF61_RS06895	1518785..1520101	-	1317	WP_151184577.1	type II toxin-antitoxin system HipA family toxin	Toxin
FXF61_RS06900	1520095..1520424	-	330	WP_151184578.1	helix-turn-helix domain-containing protein	Antitoxin
FXF61_RS06905	1520773..1521843	+	1071	WP_151184579.1	hypothetical protein	-
FXF61_RS06910	1521965..1522216	+	252	WP_151184580.1	helix-turn-helix domain-containing protein	-
FXF61_RS06915	1522206..1523444	+	1239	WP_151184581.1	type II toxin-antitoxin system HipA family toxin	-
FXF61_RS06920	1523604..1524935	+	1332	WP_151184582.1	HipA domain-containing protein	-
FXF61_RS06925	1524935..1525201	+	267	WP_151186029.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (174-410)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 48909.57 Da
• Isoelectric Point: 5.6157

>T138353 WP_151184577.1 NZ_CP043320:c1520101-1518785 [Pseudomonas sp. C27(2019)]
MVMEVINVRFKQHEVGAVSFDTQTGLGAFEYAPSFIDKGIELSPLKMPLAQGIYSFPELDFNTFKGLPGLVADSLPDDFG
NAVLNAWVAMRGKSPNDITPLQRLQYTGARGMGALEYAPATQIKSLNASQQVDIDSLLSIAQAILNARNDFSVELNQNHA
DDREGMLALLSVGMSAGGARPKAVLAFNADFTQARSGQTDAPEGFTHYLMKFDGVSEHNENQETFGDPLGFGAMEFVYYL
MAKDCGIDMMPCHLLPEGQRRHFITQRFDRVGNEKVHVQTLNGLAHVDYKKPGSFSYAELFAVLRQLKLSAVDAEQLFRR
MVFNIVARNHDDHAKNFGFMLRGDKWGLAPAYDLAYSYKPGSKWVNSHWMSLNGKRDDFVREDFYSLEKLSPLFSRSFIN
SVIDEVIEKVAGWERLATEAQVPRILIDEVAQNLRLGI

Nucleotide

• Length: 1317 bp

>T138353 NZ_CP057630:c4339972-4339496 [Citrobacter sp. RHB20-C16]
ATGGATTTTCCCACATGGCTGAACGGGTGGACGATCTACGCTCATCCCTGTTTTATCGATCAATACAACGCGCTGGTCGC
ACGTGTTGAAGACCTTAAGCACAGGTTTCCAGATCCCATTGTTTTCCAGAAGAAGAAAGAGACCAAGGTGCTGGCGCATT
TATTGAAATCCATTGCCAACATTACCCACGAACCCCGAGCTTCTGTTTACCGGCCTGGTGACAGTATAGGGAAAGCTTAT
ACAGACTGGTCGAGAGCGAAGTTTGGTGGAGGACGGTATCGCTTATTTTTCCGTTATAGTCTCGAGAGTAAGATCATTGT
CATCGCATGGGTGAATGATGAAGGGCCATTGCGCACCTACGGCAGCAAGACCGATGCCTATAAGATTTTCGGGAAAATGC
TTGATGAGGGGAATCCACCCGACGACTGGCTAAGTTTGCTTCAGGCTTGTCAAAACGACGGGAAGGAACATCTTTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12000.65 Da
• Isoelectric Point: 7.0167

>AT138353 WP_151184578.1 NZ_CP043320:c1520424-1520095 [Pseudomonas sp. C27(2019)]
MSLSNLSASAIAEELGERLKQARLNQNLTQAEVAESVGVSRRQVLNAEKGKAQLEVFVAILLALNLTGHLELFLPKQQIS
PLQLAQLQGRQRQRASGQKTAEQEGEPEW

Nucleotide

• Length: 330 bp

>AT138353 NZ_CP043320:c1520424-1520095 [Pseudomonas sp. C27(2019)]
ATGAGTCTTTCGAATTTGTCAGCATCTGCTATCGCAGAAGAGCTCGGCGAGCGTTTAAAGCAAGCGCGGCTGAATCAAAA
TCTGACCCAGGCAGAAGTGGCTGAGTCTGTTGGTGTGAGTCGCAGGCAGGTTCTCAATGCCGAAAAAGGCAAGGCTCAAC
TTGAGGTATTTGTGGCTATTTTGCTCGCATTAAATCTAACCGGCCATTTGGAACTGTTCTTGCCAAAACAGCAGATATCT
CCGTTGCAGCTTGCCCAGTTGCAAGGTCGGCAGCGACAACGCGCTTCAGGACAAAAAACAGCAGAGCAAGAGGGTGAACC
CGAATGGTAA