Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4189170..4189827 Replicon chromosome
Accession NZ_CP043318
Organism Enterobacter chengduensis strain WCHECl-C4 = WCHECh050004

Toxin (Protein)


Gene name cptA Uniprot ID A0A2T9UX79
Locus tag FY206_RS20265 Protein ID WP_032643262.1
Coordinates 4189170..4189580 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag FY206_RS20270 Protein ID WP_006178375.1
Coordinates 4189561..4189827 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY206_RS20245 4185163..4186896 - 1734 WP_032643256.1 single-stranded-DNA-specific exonuclease RecJ -
FY206_RS20250 4186902..4187615 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FY206_RS20255 4187644..4188540 - 897 WP_032643259.1 site-specific tyrosine recombinase XerD -
FY206_RS20260 4188642..4189163 + 522 WP_032643260.1 flavodoxin FldB -
FY206_RS20265 4189170..4189580 - 411 WP_032643262.1 protein YgfX Toxin
FY206_RS20270 4189561..4189827 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
FY206_RS20275 4190120..4191100 + 981 WP_032643264.1 tRNA-modifying protein YgfZ -
FY206_RS20280 4191178..4192113 - 936 WP_032638800.1 IS110 family transposase -
FY206_RS20285 4192344..4193003 - 660 WP_032643266.1 hemolysin III family protein -
FY206_RS20290 4193269..4194000 + 732 WP_032643270.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16157.07 Da        Isoelectric Point: 10.8265

>T138351 WP_032643262.1 NZ_CP043318:c4189580-4189170 [Enterobacter chengduensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNYGMMLRLRNVEGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T138351 NZ_CP043318:c4189580-4189170 [Enterobacter chengduensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TGCGCAGCCAGCGTCGCATTAATGCTCGTCAGGGAGAAATTAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTACGGCATGATGCTACGGTTACGCAACGTAGAGGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGACGCTGCCGAATGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT138351 WP_006178375.1 NZ_CP043318:c4189827-4189561 [Enterobacter chengduensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138351 NZ_CP057630:c4010120-4009854 [Citrobacter sp. RHB20-C16]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAATACGACACGTTGAGTGATGATGAAAAACGTATTTTTATCCGCCTGCTGGAGTGTGATGACCCGGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTACGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T9UX79

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References