Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 1134379..1135058 | Replicon | chromosome |
| Accession | NZ_CP043318 | ||
| Organism | Enterobacter chengduensis strain WCHECl-C4 = WCHECh050004 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | S1FHS4 |
| Locus tag | FY206_RS05590 | Protein ID | WP_000854680.1 |
| Coordinates | 1134379..1134720 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | A0A5C1BXL1 |
| Locus tag | FY206_RS05595 | Protein ID | WP_023336793.1 |
| Coordinates | 1134741..1135058 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FY206_RS05550 | 1129693..1130127 | + | 435 | WP_048212526.1 | hypothetical protein | - |
| FY206_RS05555 | 1130186..1131025 | + | 840 | WP_023303145.1 | hypothetical protein | - |
| FY206_RS05565 | 1131715..1132536 | + | 822 | WP_023303146.1 | DUF945 domain-containing protein | - |
| FY206_RS05570 | 1132602..1133072 | + | 471 | WP_023303147.1 | DNA repair protein RadC | - |
| FY206_RS05575 | 1133085..1133411 | + | 327 | WP_023303148.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| FY206_RS05580 | 1133432..1133800 | + | 369 | WP_023303149.1 | TA system toxin CbtA family protein | - |
| FY206_RS05590 | 1134379..1134720 | - | 342 | WP_000854680.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| FY206_RS05595 | 1134741..1135058 | - | 318 | WP_023336793.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| FY206_RS05600 | 1135077..1135298 | - | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| FY206_RS05605 | 1135307..1135783 | - | 477 | WP_023336794.1 | RadC family protein | - |
| FY206_RS05610 | 1135799..1136257 | - | 459 | WP_000211838.1 | antirestriction protein | - |
| FY206_RS05615 | 1136355..1136594 | - | 240 | WP_000194654.1 | DUF905 domain-containing protein | - |
| FY206_RS05620 | 1136671..1137138 | - | 468 | WP_001581459.1 | hypothetical protein | - |
| FY206_RS05625 | 1137162..1137605 | - | 444 | WP_000824223.1 | hypothetical protein | - |
| FY206_RS05630 | 1137605..1137841 | - | 237 | WP_001144031.1 | hypothetical protein | - |
| FY206_RS05635 | 1137882..1138583 | - | 702 | WP_006812588.1 | WYL domain-containing protein | - |
| FY206_RS05640 | 1138800..1139621 | - | 822 | WP_000197389.1 | DUF945 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12892.95 Da Isoelectric Point: 9.6543
>T138338 WP_000854680.1 NZ_CP043318:c1134720-1134379 [Enterobacter chengduensis]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T138338 NZ_CP043318:c1134720-1134379 [Enterobacter chengduensis]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAACGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAACGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 12016.63 Da Isoelectric Point: 7.0270
>AT138338 WP_023336793.1 NZ_CP043318:c1135058-1134741 [Enterobacter chengduensis]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDFTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDFTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT138338 NZ_CP043318:c1135058-1134741 [Enterobacter chengduensis]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTTACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTTACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1FHS4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5C1BXL1 |