Detailed information of TA system TA138337

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1133085..1133800
• Replicon: chromosome
• Accession: NZ_CP043318
• Organism: Enterobacter chengduensis strain WCHECl-C4 = WCHECh050004

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A8I0UM05
• Locus tag: FY206_RS05580
• Protein ID: WP_023303149.1
• Coordinates: 1133432..1133800 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8I0UJV2
• Locus tag: FY206_RS05575
• Protein ID: WP_023303148.1
• Coordinates: 1133085..1133411 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY206_RS05545	1128119..1129384	+	1266	WP_077064281.1	hypothetical protein	-
FY206_RS05550	1129693..1130127	+	435	WP_048212526.1	hypothetical protein	-
FY206_RS05555	1130186..1131025	+	840	WP_023303145.1	hypothetical protein	-
FY206_RS05565	1131715..1132536	+	822	WP_023303146.1	DUF945 domain-containing protein	-
FY206_RS05570	1132602..1133072	+	471	WP_023303147.1	DNA repair protein RadC	-
FY206_RS05575	1133085..1133411	+	327	WP_023303148.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FY206_RS05580	1133432..1133800	+	369	WP_023303149.1	TA system toxin CbtA family protein	Toxin
FY206_RS05590	1134379..1134720	-	342	WP_000854680.1	type IV toxin-antitoxin system toxin YkfI	-
FY206_RS05595	1134741..1135058	-	318	WP_023336793.1	type IV toxin-antitoxin system antitoxin YafW	-
FY206_RS05600	1135077..1135298	-	222	WP_000691994.1	DUF987 domain-containing protein	-
FY206_RS05605	1135307..1135783	-	477	WP_023336794.1	RadC family protein	-
FY206_RS05610	1135799..1136257	-	459	WP_000211838.1	antirestriction protein	-
FY206_RS05615	1136355..1136594	-	240	WP_000194654.1	DUF905 domain-containing protein	-
FY206_RS05620	1136671..1137138	-	468	WP_001581459.1	hypothetical protein	-
FY206_RS05625	1137162..1137605	-	444	WP_000824223.1	hypothetical protein	-
FY206_RS05630	1137605..1137841	-	237	WP_001144031.1	hypothetical protein	-
FY206_RS05635	1137882..1138583	-	702	WP_006812588.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13727.91 Da
• Isoelectric Point: 8.2822

>T138337 WP_023303149.1 NZ_CP043318:1133432-1133800 [Enterobacter chengduensis]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Nucleotide

• Length: 369 bp

>T138337 NZ_CP057611:c3955602-3955282 [Citrobacter sp. RHB21-C05]
ATGCAAATCTCAACTGTACCGGCCACGATGCCGGTTTCGTCACGCCTGTCGCCCGTGCAGGTCTGGCAGCAATTGTTAAC
GTATCTGCTGGAGCACCATTACGGCCTGACGCTCAACGACACACCATTCCATGATGATGCGGCCATCAAGGAACATATCG
AGGCGGGTATCACGCTTGCTGATGCGGTGAATTTCCTGGTGGAACGTTATGAACTGGTACGCACTGATCGCAAGGGGTTT
ACGTGGCAGGAGCAGACACCATTTGTAACCGCTACAGATATTCTCAGAGCCAGAAGAGCTACCGGGCTGATGAATAAGTA
A

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12215.04 Da
• Isoelectric Point: 7.0266

>AT138337 WP_023303148.1 NZ_CP043318:1133085-1133411 [Enterobacter chengduensis]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 327 bp

>AT138337 NZ_CP057611:c3956005-3955670 [Citrobacter sp. RHB21-C05]
ATGTATAAAGACGCTACACCAACCTGGGGGCTTAGACGAGATATCACTCCGTGTTTCGGAGCCCGACTGGTGCAGGAAGG
TCATCGCCTGCATTTTCTGGCTAACCGGGCAGGATTCACCGGCTCATTCAGTGAGGTGCAGACCTTACAACTGAATGAAG
CCTTCCCGCATTTTGTCGCATATCTGGAGCTGATGCTGCTCTCCTGCGAGCTGAATCCCCGGTACGCGCACTGTGTCACA
CTGTACCGTAACGGGTTGACTTGTGAAGCAGATACGCTGGGCAGTCATGGGCACGTGTATATGGCAATTTATCCCTCAAA
TCAGGTTAAAGACTGA