Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 168894..169498 Replicon chromosome
Accession NZ_CP043318
Organism Enterobacter chengduensis strain WCHECl-C4 = WCHECh050004

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C1BTW3
Locus tag FY206_RS00820 Protein ID WP_072001253.1
Coordinates 168894..169079 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5C1BU84
Locus tag FY206_RS00825 Protein ID WP_032644451.1
Coordinates 169094..169498 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY206_RS00805 165326..166864 + 1539 WP_032644447.1 aldehyde dehydrogenase AldB -
FY206_RS00810 166861..167823 - 963 WP_032644448.1 LysR family transcriptional regulator -
FY206_RS00815 167944..168684 + 741 WP_032644449.1 MipA/OmpV family protein -
FY206_RS00820 168894..169079 + 186 WP_072001253.1 type II toxin-antitoxin system HicA family toxin Toxin
FY206_RS00825 169094..169498 + 405 WP_032644451.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FY206_RS00830 169554..171503 - 1950 WP_032644452.1 glycoside hydrolase family 127 protein -
FY206_RS00835 171514..172914 - 1401 WP_032644453.1 MFS transporter -
FY206_RS00840 173140..173949 + 810 WP_032644454.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6852.04 Da        Isoelectric Point: 11.2341

>T138334 WP_072001253.1 NZ_CP043318:168894-169079 [Enterobacter chengduensis]
VKSADVITVLLGHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T138334 NZ_CP043318:168894-169079 [Enterobacter chengduensis]
GTGAAAAGTGCGGATGTCATTACTGTTCTGCTCGGCCATGGCTGGAAATGCGTCAGAACGAAAGGAAGCCATCATCAGTT
TCGCCATCCAGAACAGAAAGGGCTGGTTACTGTCCCACATCCTAAAAAGGATATTAAACCGGGCACTCTCGCCCAGATCT
GGCGGCAGGCGGGAATTAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14980.79 Da        Isoelectric Point: 4.3288

>AT138334 WP_032644451.1 NZ_CP043318:169094-169498 [Enterobacter chengduensis]
MFYPAYIHSDSDGSASGFFPDVPGCYFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGNVEAHLEGRPEDFIGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFANRSAFLAEAARRVLP

Download         Length: 405 bp

>AT138334 NZ_CP057611:2664349-2664588 [Citrobacter sp. RHB21-C05]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C1BTW3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BU84

References