Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4277393..4278021 Replicon chromosome
Accession NZ_CP043317
Organism Streptomyces olivaceus strain SCSIO T05

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FYC74_RS18260 Protein ID WP_194276763.1
Coordinates 4277393..4277803 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FYC74_RS18265 Protein ID WP_031046014.1
Coordinates 4277800..4278021 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC74_RS18235 4272898..4274211 + 1314 WP_194276761.1 VCBS repeat-containing protein -
FYC74_RS18240 4274338..4275282 + 945 WP_194276762.1 YIP1 family protein -
FYC74_RS18245 4275350..4275847 - 498 WP_031043808.1 phosphoribosyltransferase -
FYC74_RS18250 4275873..4276448 - 576 WP_031043809.1 dCTP deaminase -
FYC74_RS18260 4277393..4277803 - 411 WP_194276763.1 PIN domain-containing protein Toxin
FYC74_RS18265 4277800..4278021 - 222 WP_031046014.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FYC74_RS18270 4278199..4278891 + 693 WP_194276764.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
FYC74_RS18275 4279055..4280194 + 1140 WP_194276765.1 FAD-dependent monooxygenase -
FYC74_RS18280 4280242..4281138 - 897 WP_194276766.1 XRE family transcriptional regulator -
FYC74_RS18285 4281135..4282001 - 867 WP_194276767.1 peptidoglycan-binding protein -
FYC74_RS18290 4282295..4282669 + 375 WP_194276768.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-42)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14915.50 Da        Isoelectric Point: 5.4098

>T138332 WP_194276763.1 NZ_CP043317:c4277803-4277393 [Streptomyces olivaceus]
VMYLLDTSGLVRLLRDANLQSAWHDAIDAGAIASCYVQRTEFLYSARNRSEYDEIAEMFSDLYPDAAVPKNAGRWISAVQ
HRMAQAGEHRSASAVDLVIAATAAHHGLTVLHDDADYGTVARHASDLNEHNVHDVA

Download         Length: 411 bp

>T138332 NZ_CP057611:253441-253716 [Citrobacter sp. RHB21-C05]
ATGAGGCAGCAGGTGTTATCCTTGCGGAAAAAGCAAAGGAATATGCTGGAGCAACTCTTTAAAACGCCTGTACCACAAGC
AATAAAGTGGTTAGACATAGAGTCTCTGGTCAAAGCGTTAGGCGGTGAAATTAAAGAAGGACGCGGCTCTCGATGCAAAT
TCTTATTAAACAATAGTATTGCTTGTTTTCACCGACCGCATCCTTCACCGGATACAGATAAAGGCGCAGTGGAGAGTGTG
CGCGACTGGCTAATAAGCATAGGGGTTAAACCATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8585.65 Da        Isoelectric Point: 7.4050

>AT138332 WP_031046014.1 NZ_CP043317:c4278021-4277800 [Streptomyces olivaceus]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALHFYAEQQERAARISRHFERAREWGAVEDAERLHRVEKRSR

Download         Length: 222 bp

>AT138332 NZ_CP043317:c4278021-4277800 [Streptomyces olivaceus]
ATGTCCGTGACCCAGATCGACATCGATGACGACGCCCTGGAGCGCGCCATGGCTCTGGCCCATGTCCGGACCAAGAAGGA
GGCGGTCAATCTCGCCCTGCATTTCTACGCCGAGCAGCAGGAACGTGCGGCGCGCATCAGCCGTCACTTCGAGCGTGCCC
GCGAGTGGGGTGCCGTCGAGGACGCCGAGCGCCTGCACAGGGTGGAGAAGCGCAGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References