Detailed information of TA system TA138331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3237371..3237896
• Replicon: chromosome
• Accession: NZ_CP043317
• Organism: Streptomyces olivaceus strain SCSIO T05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FYC74_RS13575
• Protein ID: WP_194276154.1
• Coordinates: 3237633..3237896 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FYC74_RS13570
• Protein ID: WP_194276153.1
• Coordinates: 3237371..3237640 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYC74_RS13555	3233418..3234974	-	1557	WP_194276150.1	carboxylesterase family protein	-
FYC74_RS13560	3235001..3235915	-	915	WP_194276151.1	MBL fold metallo-hydrolase	-
FYC74_RS13565	3236093..3237034	-	942	WP_194276152.1	helix-turn-helix transcriptional regulator	-
FYC74_RS13570	3237371..3237640	+	270	WP_194276153.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FYC74_RS13575	3237633..3237896	+	264	WP_194276154.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYC74_RS13580	3238174..3240354	-	2181	WP_194276155.1	DEAD/DEAH box helicase	-
FYC74_RS13585	3240501..3240752	+	252	WP_164278816.1	hypothetical protein	-
FYC74_RS13590	3240752..3241135	+	384	WP_194276156.1	DNA-binding protein	-
FYC74_RS13595	3241263..3242351	-	1089	WP_194276157.1	redox-regulated ATPase YchF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10085.58 Da
• Isoelectric Point: 9.6560

>T138331 WP_194276154.1 NZ_CP043317:3237633-3237896 [Streptomyces olivaceus]
VSEYRTVFRPEAQAELRKIPRDMALRILTKLTELESDPLGHHTTALVSQPERRRLRVGDYRVVYTIDKGELVVWVVHVGH
RSTVHEA

Nucleotide

• Length: 264 bp

>T138331 NZ_CP057568:c1975-1628 [Escherichia fergusonii]
ATGTGGACGGTACTTTTTAGCCAGCGATTTGACGACTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGC
TGATTTGAAAAATCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTAAAAGGTTCTCGGTACAAAA
ATATGAAAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGCCGGGCCATC
GTTCTTTGTGCAGGAGACAAAAGTAACGATAAGCGGTTTTATAAAAAACTGGTGCGTATAGCTGAGGATGAGTTTGCAGC
ACATCTGAACACACTGGAGAGCAAGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10286.78 Da
• Isoelectric Point: 4.7574

>AT138331 WP_194276153.1 NZ_CP043317:3237371-3237640 [Streptomyces olivaceus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQIAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEEI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT138331 NZ_CP057568:c1628-1329 [Escherichia fergusonii]
ATGAGAACATTAGATGAGGTGATTGCCAGCCGTTCACCGGAAAGCCAGGCGCGAATTAAAGAAATGGCAGATGAGATGAT
TCTTGAGGTCGGCTTGCAGATGATGCGTGAAGAACTCCAGTTATCACAAAAACAGGTTGCTGAAGCGATGGGTATAAGCC
AGCCAGCAGTAACAAAGCTGGAGCAGCGCGGAAATGATTTAAAGCTGGCGACGTTAAAGCGTTACGTTGAAGCTATGGGA
GGCAAATTAAGCCTGGATGTTGAGCTTCCCACAGGAAAGCGAGTAGCGTTCCATGTCTAA