Detailed information of TA system TA138327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-RelB
• Location: 21279..21792
• Replicon: plasmid pAcsw19-3
• Accession: NZ_CP043310
• Organism: Acinetobacter johnsonii strain Acsw19

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: N8YGB2
• Locus tag: FYN22_RS18405
• Protein ID: WP_000184943.1
• Coordinates: 21279..21542 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N8ZW56
• Locus tag: FYN22_RS18410
• Protein ID: WP_000557944.1
• Coordinates: 21529..21792 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYN22_RS18380	16448..16852	+	405	WP_148827135.1	hypothetical protein	-
FYN22_RS18385	17114..17401	-	288	WP_004870774.1	hypothetical protein	-
FYN22_RS18390	17398..18339	-	942	WP_020846814.1	replication initiation protein	-
FYN22_RS18395	19051..20703	-	1653	WP_004870770.1	MobA/MobL family protein	-
FYN22_RS18400	20915..21217	+	303	WP_000110201.1	hypothetical protein	-
FYN22_RS18405	21279..21542	-	264	WP_000184943.1	Txe/YoeB family addiction module toxin	Toxin
FYN22_RS18410	21529..21792	-	264	WP_000557944.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FYN22_RS18415	21928..22407	-	480	WP_065995571.1	cysteine hydrolase family protein	-
FYN22_RS18420	23366..23935	-	570	WP_148827134.1	hypothetical protein	-
FYN22_RS18425	24143..24547	+	405	WP_148827135.1	hypothetical protein	-
FYN22_RS18430	24809..25096	-	288	WP_004870774.1	hypothetical protein	-
FYN22_RS18435	25093..26034	-	942	WP_020846814.1	replication initiation protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..38391	38391

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10649.09 Da
• Isoelectric Point: 8.4866

>T138327 WP_000184943.1 NZ_CP043310:c21542-21279 [Acinetobacter johnsonii]
MTNRNVEWTDNAWDEYIYWQTQDKKILKRINTLIKECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
IQCRFHY

Nucleotide

• Length: 264 bp

>T138327 NZ_CP057565:c4300373-4300221 [Escherichia fergusonii]
ATGCCGCAGAAATACGGATTACTTTCGTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGAGAATTATGAGCTGGCGGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.99 Da
• Isoelectric Point: 5.0829

>AT138327 WP_000557944.1 NZ_CP043310:c21792-21529 [Acinetobacter johnsonii]
MHVFTYTDARNNLKSVLDKVIDDVDVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNASRLNESIAQLRAGKTKHRE
LIEDDES

Nucleotide

• Length: 264 bp

>AT138327 NZ_CP057565:4300424-4300479 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A6C0XPS2

Antitoxin

• AlphaFold DB: A0A6C0XPU2