Detailed information of TA system TA138320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2864340..2865116
• Replicon: chromosome
• Accession: NZ_CP043302
• Organism: Staphylococcus aureus strain 16445

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: FQP84_RS14835
• Protein ID: WP_000031108.1
• Coordinates: 2864340..2864492 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: FQP84_RS14840
• Protein ID: WP_031806872.1
• Coordinates: 2864517..2865116 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQP84_RS14815	2860420..2861241	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
FQP84_RS14820	2861704..2863089	-	1386	WP_000116224.1	class II fumarate hydratase	-
FQP84_RS14825	2863285..2863680	-	396	WP_000901021.1	hypothetical protein	-
FQP84_RS14835	2864340..2864492	-	153	WP_000031108.1	hypothetical protein	Toxin
FQP84_RS14840	2864517..2865116	-	600	WP_031806872.1	glucosamine-6-phosphate isomerase	Antitoxin
FQP84_RS14845	2865275..2865745	-	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
FQP84_RS14850	2865750..2866877	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
FQP84_RS14855	2867028..2867750	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
FQP84_RS14860	2867743..2869200	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T138320 WP_000031108.1 NZ_CP043302:c2864492-2864340 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T138320 NZ_CP043302:c2864492-2864340 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22333.43 Da
• Isoelectric Point: 5.1445

>AT138320 WP_031806872.1 NZ_CP043302:c2865116-2864517 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQASVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT138320 NZ_CP057565:1377811-1378038 [Escherichia fergusonii]
ATGGAAACCACTGTATTTTTAAGTAATCGCAGTCAGGCTGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGACGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Structures

Toxin

• AlphaFold DB: X5E2E6