Detailed information of TA system TA138317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 1972751..1973539
• Replicon: chromosome
• Accession: NZ_CP043302
• Organism: Staphylococcus aureus strain 16445

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2I7Y5B3
• Locus tag: FQP84_RS10265
• Protein ID: WP_000525004.1
• Coordinates: 1972751..1973212 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FQP84_RS10270
• Protein ID: WP_149590289.1
• Coordinates: 1973225..1973539 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQP84_RS10245	1968104..1968664	-	561	WP_000149686.1	cysteine hydrolase	-
FQP84_RS10250	1969036..1970133	+	1098	WP_000275730.1	pectate lyase	-
FQP84_RS10255	1970338..1970991	+	654	Protein_1959	anion permease	-
FQP84_RS10260	1971016..1972401	-	1386	WP_000861313.1	recombinase family protein	-
FQP84_RS10265	1972751..1973212	-	462	WP_000525004.1	hypothetical protein	Toxin
FQP84_RS10270	1973225..1973539	-	315	WP_149590289.1	helix-turn-helix domain-containing protein	Antitoxin
FQP84_RS10275	1973691..1973927	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
FQP84_RS10280	1973941..1974717	+	777	WP_001148544.1	Rha family transcriptional regulator	-
FQP84_RS15650	1974746..1974916	+	171	WP_000398751.1	hypothetical protein	-
FQP84_RS10285	1974905..1975114	-	210	WP_000033736.1	hypothetical protein	-
FQP84_RS10290	1975171..1975914	+	744	WP_001148623.1	phage antirepressor KilAC domain-containing protein	-
FQP84_RS10295	1976090..1976320	-	231	WP_000395455.1	hypothetical protein	-
FQP84_RS10300	1976500..1976661	+	162	WP_000066021.1	DUF1270 family protein	-
FQP84_RS10305	1976753..1977013	+	261	WP_000291089.1	DUF1108 family protein	-
FQP84_RS10310	1977023..1977244	+	222	WP_000815403.1	DUF2483 family protein	-
FQP84_RS10315	1977237..1977860	+	624	WP_000139720.1	DUF1071 domain-containing protein	-
FQP84_RS10320	1977860..1978288	+	429	WP_000934784.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1969036..2013778	44742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18074.46 Da
• Isoelectric Point: 4.6915

>T138317 WP_000525004.1 NZ_CP043302:c1973212-1972751 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T138317 NZ_CP057565:c679678-679469 [Escherichia fergusonii]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11991.50 Da
• Isoelectric Point: 7.1659

>AT138317 WP_149590289.1 NZ_CP043302:c1973539-1973225 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGGLTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT138317 NZ_CP057565:679670-679727 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: A0A2I7Y5B3