Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1845740..1846269 Replicon chromosome
Accession NZ_CP043302
Organism Staphylococcus aureus strain 16445

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FQP84_RS09485 Protein ID WP_000621175.1
Coordinates 1845907..1846269 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag FQP84_RS09480 Protein ID WP_000948331.1
Coordinates 1845740..1845910 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQP84_RS09450 1840777..1841337 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
FQP84_RS09455 1841545..1842024 + 480 WP_001287088.1 hypothetical protein -
FQP84_RS09460 1842017..1843600 + 1584 WP_001294626.1 PH domain-containing protein -
FQP84_RS09465 1843587..1844078 + 492 WP_001205910.1 PH domain-containing protein -
FQP84_RS09470 1844082..1844441 + 360 WP_000581200.1 holo-ACP synthase -
FQP84_RS09475 1844507..1845655 + 1149 WP_001281145.1 alanine racemase -
FQP84_RS09480 1845740..1845910 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
FQP84_RS09485 1845907..1846269 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FQP84_RS09490 1846618..1847619 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
FQP84_RS09495 1847738..1848064 + 327 WP_001052491.1 anti-sigma factor antagonist -
FQP84_RS09500 1848066..1848545 + 480 WP_001190829.1 anti-sigma B factor RsbW -
FQP84_RS09505 1848520..1849290 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T138313 WP_000621175.1 NZ_CP043302:1845907-1846269 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T138313 NZ_CP057562:81978-82130 [Escherichia fergusonii]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT138313 WP_000948331.1 NZ_CP043302:1845740-1845910 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT138313 NZ_CP057562:c81928-81866 [Escherichia fergusonii]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References