138312

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1825999..1826513 Replicon chromosome
Accession NZ_CP043302
Organism Staphylococcus aureus strain 16445

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FQP84_RS09395 Protein ID WP_000581792.1
Coordinates 1826304..1826513 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag FQP84_RS09390 Protein ID WP_000138932.1
Coordinates 1825999..1826292 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQP84_RS09355 1821262..1821903 + 642 WP_000483153.1 thiamine phosphate synthase -
FQP84_RS09360 1821989..1822861 + 873 WP_000725802.1 membrane protein insertase YidC -
FQP84_RS09380 1823674..1824321 - 648 WP_001187629.1 HD domain-containing protein -
FQP84_RS09385 1824349..1825833 - 1485 WP_149590286.1 cardiolipin synthase -
FQP84_RS09390 1825999..1826292 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
FQP84_RS09395 1826304..1826513 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FQP84_RS09400 1826641..1826778 + 138 WP_000828354.1 hypothetical protein -
FQP84_RS09405 1827042..1828244 - 1203 WP_001109939.1 rod shape-determining protein RodA -
FQP84_RS09410 1828562..1829632 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
FQP84_RS09415 1829647..1831005 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T138312 WP_000581792.1 NZ_CP043302:1826304-1826513 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T138312 NZ_CP043302:1826304-1826513 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT138312 WP_000138932.1 NZ_CP043302:1825999-1826292 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT138312 NZ_CP057562:1989-2258 [Escherichia fergusonii]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGTCAGACTGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGAAGGACGTCAGCAACTCGAACGCGGTGATGTGCTTCCCCATGACATAGTCGAATCCTCCGCTGCTGCATGGCGGGAT
GAGATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References