Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 291158..291635 Replicon chromosome
Accession NZ_CP043302
Organism Staphylococcus aureus strain 16445

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag FQP84_RS01685 Protein ID WP_000052078.1
Coordinates 291447..291635 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FQP84_RS01680 Protein ID WP_001059690.1
Coordinates 291158..291418 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQP84_RS01645 286551..287267 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
FQP84_RS01650 287415..287837 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
FQP84_RS01655 288236..288730 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
FQP84_RS01660 288885..289502 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FQP84_RS01665 289575..290156 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
FQP84_RS01670 290381..290617 + 237 WP_000368687.1 hypothetical protein -
FQP84_RS01675 290614..290817 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FQP84_RS01680 291158..291418 + 261 WP_001059690.1 hypothetical protein Antitoxin
FQP84_RS01685 291447..291635 + 189 WP_000052078.1 hypothetical protein Toxin
FQP84_RS01690 291823..292392 + 570 WP_001106654.1 hypothetical protein -
FQP84_RS01695 292480..292764 + 285 WP_001004395.1 hypothetical protein -
FQP84_RS01700 292826..293044 + 219 WP_000005886.1 hypothetical protein -
FQP84_RS01705 293540..293740 - 201 WP_001059082.1 cold-shock protein -
FQP84_RS01710 294097..294783 - 687 WP_001548082.1 thermonuclease family protein -
FQP84_RS01715 295124..295594 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb / selq / selk 263687..296951 33264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T138303 WP_000052078.1 NZ_CP043302:291447-291635 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T138303 NZ_CP057561:1195702-1196004 [Escherichia fergusonii]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT138303 WP_001059690.1 NZ_CP043302:291158-291418 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT138303 NZ_CP057561:1196040-1196381 [Escherichia fergusonii]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCTCGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References